| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
Sphingomyelin Synthase 1 |
| Specificity: |
This antibody reacts specifically with Sphingomyelin Synthase 1 |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Subcellular locations: |
Intracellular |
| Antigen Source: |
KLH conjugated synthetic peptide derived from human Sphingomyelin Synthase 1 |
| Gene ID: |
259230 |
| Swiss Prot: |
Q86VZ5 |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
Golgi apparatus SMS1 directly and specifically recognizes the choline head group on the substrate, Major form in macrophages, May protect against cell death by reversing the stress-inducible increase in levels of proapoptotic ceramide, Required for cell growth in certain cell types such as HeLa cells, Suppresses BAX-mediated apoptosis and also prevents cell death in response to stimuli such as hydrogen peroxide, The reaction is bidirectional depending on the respective levels of the sphingolipid and ceramide, elevated temperature and exogenously supplied sphingolipids, on to the primary hydroxyl of ceramide, osmotic stress, phosphatidylcholine, requiring two fatty chains on the choline-P donor molecule in order to be recognized efficiently as a substrate, sphingomyelin, through transfer of the phosphatidyl head group, Sphingomyelin synthases synthesize the sphingolipid |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
MOB1, Medulla oblongata-derived protein, Phosphatidylcholine:ceramide cholinephosphotransferase 1, Protein Mob, SGMS1, SMS1, Sphingomyelin synthase 1, TMEM23, Transmembrane protein 23, hmob33, MOB |
| Also known as: |
Sphingomyelin Synthase 1 Antibody |
| Other name: |
Anti-Sphingomyelin Synthase 1 |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Gene target: |
Sphingomyelin Synthase 1 |
| Short name: |
Fluor 594, Anti-Sphingomyelin Synthase 1 |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, antibody to-Sphingomyelin Synthase 1 |