| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
TXNIP |
| Specificity: |
This antibody reacts specifically with TXNIP |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Subcellular locations: |
Cytoplasm |
| Antigen Source: |
KLH conjugated synthetic peptide derived from human TXNIP |
| Gene ID: |
10628 |
| Swiss Prot: |
Q9H3M7 |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
Acts as a suppressor of tumor cell growth, Functions as a transcriptional repressor, Inhibits the proteasomal degradation of DDIT4, Interacts with COPS5 and restores COPS5-induced suppression of CDKN1B stability, Required for the maturation of natural killer cells, and over-expression will induce G0/G1 cell cycle arrest, and thereby contributes to the inhibition of the mammalian target of rapamycin complex 1 (mTORC1), blocking the COPS5-mediated translocation of CDKN1B from the nucleus to the cytoplasm, possibly by acting as a bridge molecule between transcription factors and corepressor complexes, May act as an oxidative stress mediator by inhibiting thioredoxin activity or by limiting its bioavailability |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
VDUP1 EST01027 HHCPA78 THIF ARRDC6 |
| Also known as: |
TXNIP Polyclonal Antibody |
| Other name: |
Anti-TXNIP Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
TXNIP |
| Short name: |
Anti-TXNIP (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, antibody to-TXNIP (polyclonal) |
| Alternative technique: |
polyclonals |
| Identity: |
16952 |
| Gene: |
TXNIP |
More about : TXNIP |
| Long gene name: |
thioredoxin interacting protein |
| Synonyms name: |
upregulated by 1, 25-dihydroxyvitamin D-3 thioredoxin binding protein 2 |
| Locus: |
1q21, 1 |
| Discovery year: |
2001-12-12 |
| GenBank acession: |
S73591 |
| Entrez gene record: |
10628 |
| Pubmed identfication: |
8086474 |
| RefSeq identity: |
NM_006472 |
| Classification: |
Alpha arrestins |
| Havana BLAST/BLAT: |
OTTHUMG00000013755 |