| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
Aurora A+B+C |
| Specificity: |
This antibody reacts specifically with Aurora A+B+C |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Antigen Source: |
KLH conjugated synthetic peptide derived from human Aurora A/B/C |
| Gene ID: |
6790 |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
Aurora A is viewed as a potential target for anticancer drug treatment, Aurora A plays a key role during tumor development and progression and is overexpressed in many human cancers including breast, Aurora kinase C may play a part in organizing microtubules in relation to the function of the centrosome/spindle pole during mitosis, Aurora-C expression is maximum at M phase, Elevated expression levels are seen only in a subset of cancer cells such as HepG2, Expression is limited to testis in normal cells, HuH7 and HeLa cells, It localizes to the inner centromere region from prophase to anaphase, The Aurora kinases, This protein is localized to centrosome from anaphase to cytokinesis, and may regulate several stages of mitosis such as centrosome separation, associate with microtubules during chromosome movement and segregation, behaves as a chromosomal passenger protein, chromosome segregation and cytokinesis, in relation to the function of the centrosome/spindle pole region during chromosome segregation, members of the Ser/Thr protein kinase family, ovarian and colorectal, Aurora A plays a role in cell cycle regulation during anaphase and/or telophase, Aurora B is a mitotic protein kinase that phosphorylates histone H3 (probably on Serine 10) |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
AIE2, AIK2, AIK3, AIM1, ARK1, ARK2, AURA, AURKA, AURKA_HUMAN, AURKB, AURKC, AURKC, AURORA2, AYK1, AurB, AurC, Aurora 1, Aurora 2, Aurora A, Aurora C, Aurora Family Kinase 1, Aurora Related Kinase 1, Aurora and Ipl1 like midbody associated protein 1, Aurora kinase B, Aurora related kinase 2, Aurora-B, Aurora/IPL1 Like Kinase, Aurora/IPL1 Related Kinase 1, Aurora/IPL1 related kinase 2, Aurora/Ipl1 related kinase 3, Aurora/Ipl1/Eg2 protein 2, BRAK, BTAK, Breast Tumor Amplied Kinase, EC 2, IAK, IPL-1, IPL1, IPL1 Aurora Related Kinase 1, IPL1 Related Kinase, MGC34538, STK1, STK12, STK13, STK5, Serine threonine protein kinase 13, Serine/theronine kinase 12, Serine/threonine protein kinase 12, aurora kinase A, hARK1, 1, 7, 11, AIK |
| Also known as: |
Aurora A+B+C Polyclonal Antibody |
| Other name: |
Anti-Aurora A+B+C Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
Aurora A+B+C |
| Short name: |
Anti-Aurora A+B+C (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, antibody to-Aurora A+B+C (polyclonal) |
| Alternative technique: |
polyclonals |