| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
Polycystin 1 |
| Specificity: |
This antibody reacts specifically with Polycystin 1 |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Subcellular locations: |
Extracellular |
| Antigen Source: |
KLH conjugated synthetic peptide derived from human Polycystin 1 |
| Gene ID: |
5310 |
| Swiss Prot: |
P98161 |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Mouse (Mus musculus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
Acts as a regulator of cilium length, Involved in adhesive protein-protein and protein-carbohydrate interactions, Involved in fluid-flow mechanosensation by the primary cilium in renal epithelium, May be an ion-channel regulator, The cilium length response creates a negative feedback loop whereby fluid shear-mediated deflection of the primary cilium, The dynamic control of cilium length is essential in the regulation of mechanotransductive signaling, leads to cilium shortening and thus decreases flow-induced signaling (By similarity), together with PKD2, which decreases intracellular cAMP, Involved in renal tubulogenesis |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Also known as: |
Polycystin 1 Polyclonal Antibody |
| Other name: |
Anti-Polycystin 1 Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
Polycystin 1 |
| Short name: |
Anti-Polycystin 1 (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, antibody to-Polycystin 1 (polyclonal) |
| Alternative technique: |
polyclonals |
| Identity: |
21716 |
| Gene: |
PKD1L3 |
More about : PKD1L3 |
| Long gene name: |
polycystin 1 like 3, transient receptor potential channel interacting |
| Synonyms gene name: |
polycystic kidney disease 1-like 3 |
| Locus: |
16q22, 2 |
| Discovery year: |
2003-08-05 |
| GenBank acession: |
AY164485 |
| Entrez gene record: |
342372 |
| Pubmed identfication: |
12782129 20538909 |
| RefSeq identity: |
NM_181536 |
| Classification: |
C-type lectin domain containing |
| Havana BLAST/BLAT: |
OTTHUMG00000166114 |