| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
HIBCH |
| Specificity: |
This antibody reacts specifically with HIBCH |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Antigen Source: |
KLH conjugated synthetic peptide derived from human HIBCH |
| Gene ID: |
26275 |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
Defects to this gene result in HIBCH deficiency (HIBCHD), Existing as two alternatively spliced isoforms, HIBCH hydrolyzes HIBYL-CoA, HIBCH is highly expressed in liver and kidney, HIBCHD is characterized by the accumulation of methacrylyl-CoA, Localizing to the mitochondria, Phenotypic symptoms include early deterioration of neurological function, a highly reactive compound that undergoes addition reactions with free sulfhydryl groups, a saline catabolite, an intermediate in the minor pathway involved in the metabolism of proprionate, and Î, delayed motor skill development and hypotonia, known alternatively as deficiency of Î, muscle and brain, the gene encoding HIBCH maps to human chromosome 2q32, with lower levels found in heart, ², ², -hydroxyisobutyryl CoA deacylase or methacrylic aciduria, -hydroxypropionyl-CoA, 2, HIBCH is a 386 amino acid protein belonging to the enoyl-CoA hydratase/isomerase family |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Also known as: |
HIBCH Polyclonal Antibody |
| Other name: |
Anti-HIBCH Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
HIBCH |
| Short name: |
Anti-HIBCH (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, antibody to-HIBCH (polyclonal) |
| Alternative technique: |
polyclonals |
| Identity: |
4908 |
| Gene: |
HIBCH |
More about : HIBCH |
| Long gene name: |
3-hydroxyisobutyryl-CoA hydrolase |
| Synonyms gene name: |
3-hydroxyisobutyryl-Coenzyme A hydrolase |
| Locus: |
2q32, 2 |
| Discovery year: |
1999-12-07 |
| GenBank acession: |
U66669 |
| Entrez gene record: |
26275 |
| Pubmed identfication: |
8824301 |
| Havana BLAST/BLAT: |
OTTHUMG00000132673 |