| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
PAG1 |
| Specificity: |
This antibody reacts specifically with PAG1 |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Antigen Source: |
KLH conjugated synthetic peptide derived from human PAG1 |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
Cbp is a component of the regulatory mechanism controlling the activity of membrane-associated Src-PTKs, Cbp is exclusively localized in the GM1 ganglioside-enriched detergent-insoluble membrane domain, Cbp is involved in the membrane localization of Csk and in Csk-mediated inhibition of c-Src, Csk binding protein (Cbp), In the plasma membrane, The activity of Src-PTKs in cells of different types is negatively controlled by Csk, also designated phosphoprotein associated with glycosphingo-lipid-enriched microdomains (GEMs) or PAG, is a ubiquitously expressed transmembrane phosphoprotein that binds specifically to the SH2 domain of Csk, which is important in receptor-mediated signaling, The Src family of protein tyrosine kinases (Src-PTKs) is important in the regulation of growth and differentiation of eukaryotic cells |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
PAG CBP |
| Also known as: |
PAG1 Polyclonal Antibody |
| Other name: |
Anti-PAG1 Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
PAG1 |
| Short name: |
Anti-PAG1 (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, antibody to-phosphoprotein associated with glycosphin this GO lipid microdomains 1 (polyclonal) |
| Alternative technique: |
polyclonals |
| Alternative to gene target: |
PAG1 and IDBG-26542 and ENSG00000076641 and 55824, PAG1 and IDBG-644850 and ENSBTAG00000014026 and 614460, Pag1 and IDBG-131044 and ENSMUSG00000027508 and 94212, Plasma membranes, SH2 domain binding, this GO :0005070 and SH3/SH2 adaptor activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005886 and plasma membrane and cellular component this GO :0007165 and signal transduction and biological process this GO :0007173 and epidermal growth factor receptor signaling pathway and biological process this GO :0009967 and positive regulation of signal transduction and biological process this GO :0016021 and integral component of membrane and cellular component this GO :0035556 and intracellular signal transduction and biological process this GO :0042169 and SH2 domain binding and molecular function this GO :0045121 and membrane raft and cellular component this GO :0050852 and T cell receptor signaling pathway and biological process this GO :0050863 and regulation of T cell activation and biological process this GO :0050868 and negative regulation of T cell activation and biological process, this GO :0005070 : SH3/SH2 adaptor activity, this GO :0005070 : SH3/SH2 adaptor activity and also this GO :0005515 : protein binding and also this GO :0042169 : SH2 domain binding, this GO :0005515 : protein binding, this GO :0042169 : SH2 domain binding, phosphoprotein associated with glycosphin this GO lipid microdomains 1 |
| Identity: |
30043 |
| Gene: |
PAG1 |
More about : PAG1 |
| Long gene name: |
phosphoprotein membrane anchor with glycosphingolipid microdomains 1 |
| Synonyms gene name: |
phosphoprotein associated with glycosphingolipid microdomains 1 |
| Synonyms name: |
Csk-binding protein transmembrane adaptor protein PAG |
| Locus: |
8q21, 13 |
| Discovery year: |
2005-04-25 |
| GenBank acession: |
AF240634 |
| Entrez gene record: |
55824 |
| Pubmed identfication: |
10790433 |
| RefSeq identity: |
NM_018440 |
| Havana BLAST/BLAT: |
OTTHUMG00000164592 |