| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
GLDC |
| Specificity: |
This antibody reacts specifically with GLDC |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Antigen Source: |
KLH conjugated synthetic peptide derived from human GLDC |
| Gene ID: |
2731 |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
DLD (known as Protein L) and GLDC (known as Protein P), GCSH (known as Protein H), GCSP (glycine cleavage system P protein) or HYGN1, GLDC (glycine dehydrogenase ), GLDC binds to glycine and enables the methylamine group from glycine to be transferred to the Protein T, GLDC exists as a homodimer and utilizes pyridoxal phosphate as a cofactor, Mutations in the gene encoding GLDC leads to nonketotic hyperglycinemia (NKH), all of which work together to catalyze the cleavage and degradation of glycine, also known as GCE, also known as glycine encephalopathy (GCE), an autosomal recessive disease characterized by accumulation of a large amount of glycine in body fluid and by severe neurological symptoms, is a 1, 020 amino acid protein that localizes to the mitochondria and belongs to the gcvP family, The glycine cleavage system is comprised of AMT (known as Protein T) |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
GCSP NKH |
| Also known as: |
GLDC Polyclonal Antibody |
| Other name: |
Anti-GLDC Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
GLDC |
| Short name: |
Anti-GLDC (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, antibody to-GLDC (polyclonal) |
| Alternative technique: |
polyclonals |
| Identity: |
4313 |
| Gene: |
GLDC |
More about : GLDC |
| Long gene name: |
glycine decarboxylase |
| Synonyms gene name: |
glycine cleavage system protein P) glycine dehydrogenase (decarboxylating) , glycine decarboxylase, glycine dehydrogenase (decarboxylating |
| Synonyms name: |
glycine cleavage system protein P glycine dehydrogenase |
| Locus: |
9p24, 1 |
| Discovery year: |
1992-04-08 |
| GenBank acession: |
D90239 |
| Entrez gene record: |
2731 |
| Pubmed identfication: |
1993704 1996985 |
| RefSeq identity: |
NM_000170 |
| Havana BLAST/BLAT: |
OTTHUMG00000019524 |
| Locus Specific Databases: |
LRG_643 |