| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
FYB/ADAP |
| Specificity: |
This antibody reacts specifically with FYB/ADAP |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Antigen Source: |
KLH conjugated synthetic peptide derived from human FYB/ADAP |
| Gene ID: |
2533 |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
RKxxYxxY) (4, SKAP55 and SKAP55-R bind to Fyb through their SH3 domains and function as substrates for p59Fyn in resting T cells (1â, SKAP55 associates with SLAP-130, SKAP55 contains an amino-terminal pleckstrin homology domain and a carboxy-terminal SH3 domain binding motif of adjacent arginine and lysine residues followed by tandem tyrosines (i, SKAP55-R, The human Fyb gene maps to chromosome 5p13, another component of the Fyn complex, contains a coiled-coil N-terminal domain (1, similar in overall structure to SKAP55, which plays a role in the regulation of signaling events initiated by lymphocyte antigen receptors leading up to T cell activation (6), &euro, &euro, &ldquo, &ldquo, 1 and encodes a 783 amino acid protein (7), 2), 3), 3), 5), Fyb (Fyn binding protein) and the anchoring proteins SKAP55 (src kinase-associated phosphoprotein) and SKAP55-R (SKAP55-related protein) associate with the tyrosine kinase p59fyn (1â, e |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
SLAP-130 FYB-120/130 ADAP |
| Also known as: |
FYB/ADAP Polyclonal Antibody |
| Other name: |
Anti-FYB/ADAP Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
FYB/ADAP |
| Short name: |
Anti-FYB/ADAP (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, FGR, YES binding protein/ADAP (polyclonal), antibody to-FYN oncogene related to v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) |
| Alternative technique: |
polyclonals |
| Alternative to gene target: |
ADAP and PRO0823 and SLAP-130, FYB and IDBG-17782 and ENSG00000082074 and 2533, FYB and IDBG-629944 and ENSBTAG00000001492 and 535347, Fyb and IDBG-128115 and ENSMUSG00000022148 and 23880, nuclei, protein complex binding, this GO :0005102 and receptor binding and molecular function this GO :0005515 and protein binding and molecular function this GO :0005634 and nucleus and cellular component this GO :0005829 and cytosol and cellular component this GO :0006468 and protein phosphorylation and biological process this GO :0006607 and NLS-bearing protein import into nucleus and biological process this GO :0006955 and immune response and biological process this GO :0007165 and signal transduction and biological process this GO :0008150 and biological process and biological process this GO :0015629 and actin cytoskeleton and cellular component this GO :0032403 and protein complex binding and molecular function this GO :0035556 and intracellular signal transduction and biological process this GO :0050852 and T cell receptor signaling pathway and biological process, this GO :0005102 : receptor binding, this GO :0005102 : receptor binding and also this GO :0005515 : protein binding and also this GO :0032403 : protein complex binding, this GO :0005515 : protein binding, this GO :0032403 : protein complex binding, FYN binding protein |
| Identity: |
4036 |
| Gene: |
FYB |
More about : FYB |
| Long gene name: |
FYN binding protein |
| Synonyms gene name: |
FYN-binding protein (FYB-120/130) |
| Synonyms name: |
adhesion and degranulation promoting adaptor protein |
| Locus: |
5p13, 1 |
| Discovery year: |
1998-04-22 |
| GenBank acession: |
U93049 |
| Entrez gene record: |
2533 |
| Pubmed identfication: |
9115214 9207119 |
| RefSeq identity: |
NM_001465 |
| Havana BLAST/BLAT: |
OTTHUMG00000162071 |