| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
FMRP Ser500 |
| Specificity: |
This antibody reacts specifically with FMRP (Ser500) |
| Modification: |
Phosphorylation |
| Modification site: |
Ser500 |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Subcellular locations: |
Nucleus, Cytoplasm |
| Antigen Source: |
KLH conjugated synthetic phosphopeptide derived from human FMRP around the phosphorylation site of Ser500 |
| Gene ID: |
2332 |
| Swiss Prot: |
Q06787 |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
Associated with polysomes, Binds strongly to poly(G), Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression, In the CYFIP1-EIF4E-FMR1 complex this subunit mediates translation repression (By similarity), May play a role in the transport of mRNA from the nucleus to the cytoplasm, RNA-binding protein that plays a role in intracellular RNA transport and in the regulation of translation of target mRNAs, binds moderately to poly(U) but shows very little binding to poly(A) or poly(C), Translation repressor |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
FMRP FRAXA MGC87458 |
| Also known as: |
FMRP (Ser500) Polyclonal Antibody |
| Other name: |
Anti-FMRP (Ser500) Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
FMRP (Ser500) |
| Short name: |
Anti-FMRP (Ser500) (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, antibody to-FMRP (Ser500) (polyclonal) |
| Alternative technique: |
polyclonals |
| Identity: |
3775 |
| Gene: |
FMR1 |
More about : FMR1 |
| Long gene name: |
fragile X mental retardation 1 |
| Synonyms gene: |
POF1 POF |
| Synonyms gene name: |
premature ovarian failure 1 |
| Locus: |
Xq27, 3 |
| Discovery year: |
1992-01-17 |
| GenBank acession: |
X69962 |
| Entrez gene record: |
2332 |
| Pubmed identfication: |
1572655 |
| RefSeq identity: |
NM_002024 |
| Havana BLAST/BLAT: |
OTTHUMG00000022606 |
| Locus Specific Databases: |
Mental Retardation database LRG_762 |