| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
CCR7/CD197 |
| Specificity: |
This antibody reacts specifically with CCR7/CD197 |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Subcellular locations: |
Extracellular |
| Antigen Source: |
KLH conjugated synthetic peptide derived from mouse CCR7 |
| Gene ID: |
12775 |
| Swiss Prot: |
P47774 |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
CCR7 has been reported to be expressed in blood, ESTs have been isolated from blood, It is particularly expressed in lymphoid tissues and in activated B and T lymphocytes and has been shown to control the migration of memory T cells to inflamed tissues, The chemokine (C-C motif) ligand 19 (CCL19/ECL) has been reported to be a specific ligand of this receptor, This receptor was identified as a gene induced by the Epstein Barr virus (EBV), and intestine, and is thought to be a mediator of EBV effects on B lymphocytes, and thymus libraries, as well as stimulate dendritic cell maturation, bone marrow, embryo, lymph node, lymph node, CCR7 is a member of the G protein coupled receptor family (subfamily : chemokine) |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
BLR2 CDw197 CD197 |
| Also known as: |
CCR7/CD197 Polyclonal Antibody |
| Other name: |
Anti-CCR7/CD197 Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
CCR7/CD197 |
| Short name: |
Anti-CCR7/CD197 (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, antibody to-chemokine (C-C motif) receptor 7/CD197 (polyclonal) |
| Alternative technique: |
polyclonals |
| Alternative to gene target: |
BLR2 and CC-CKR-7 and CCR-7 and CD197 and CDw197 and CMKBR7 and EBI1, C-C motif chemokine 21 receptor activity, CCR7 and IDBG-47801 and ENSG00000126353 and 1236, CCR7 and IDBG-639725 and ENSBTAG00000015133 and 510668, Ccr7 and IDBG-210918 and ENSMUSG00000037944 and 12775, Cell surfaces, this GO :0001768 and establishment of T cell polarity and biological process this GO :0001954 and positive regulation of cell-matrix adhesion and biological process this GO :0002407 and dendritic cell chemotaxis and biological process this GO :0002408 and myeloid dendritic cell chemotaxis and biological process this GO :0002606 and positive regulation of dendritic cell antigen processing and presentation and biological process this GO :0002885 and positive regulation of hypersensitivity and biological process this GO :0002922 and positive regulation of humoral immune response and biological process this GO :0004930 and G-protein coupled receptor activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005622 and intracellular and cellular component this GO :0005886 and plasma membrane and cellular component this GO :0006935 and chemotaxis and biological process this GO :0006954 and inflammatory response and biological process this GO :0006955 and immune response and biological process this GO :0007186 and G-protein coupled receptor signaling pathway and biological process this GO :0007204 and positive regulation of cytosolic calcium ion concentration and biological process this GO :0009897 and external side of plasma membrane and cellular component this GO :0009986 and cell surface and cellular component this GO :0016021 and integral component of membrane and cellular component this GO :0016493 and C-C chemokine receptor activity and molecular function this GO :0030838 and positive regulation of actin filament polymerization and biological process this GO :0031274 and positive regulation of pseudopodium assembly and biological process this GO :0031529 and ruffle organization and biological process this GO :0032496 and response to lipopolysaccharide and biological process this GO :0032649 and regulation of interferon-gamma production and biological process this GO :0032735 and positive regulation of interleukin-12 production and biological process this GO :0032862 and activation of Rho GTPase activity and biological process this GO :0034695 and response to prostaglandin E and biological process this GO :0035757 and chemokine (C-C motif) ligand 19 binding and molecular function this GO :0035758 and chemokine (C-C motif) ligand 21 binding and molecular function this GO :0038115 and chemokine (C-C motif) ligand 19 signaling pathway and biological process this GO :0038116 and chemokine (C-C motif) ligand 21 signaling pathway and biological process this GO :0038117 and C-C motif chemokine 19 receptor activity and molecular function this GO :0038121 and C-C motif chemokine 21 receptor activity and molecular function this GO :0043123 and positive regulation of I-kappaB kinase/NF-kappaB signaling and biological process this GO :0043552 and positive regulation of phosphatidylinositol 3-kinase activity and biological process this GO :0045060 and negative thymic T cell selection and biological process this GO :0045087 and innate immune response and biological process this GO :0045785 and positive regulation of cell adhesion and biological process this GO :0045860 and positive regulation of protein kinase activity and biological process this GO :0046330 and positive regulation of JNK cascade and biological process this GO :0050706 and regulation of interleukin-1 beta secretion and biological process this GO :0050862 and positive regulation of T cell receptor signaling pathway and biological process this GO :0051209 and release of sequestered calcium ion into cytosol and biological process this GO :0051491 and positive regulation of filopodium assembly and biological process this GO :0051897 and positive regulation of protein kinase B signaling and biological process this GO :0070098 and chemokine-mediated signaling pathway and biological process this GO :0070374 and positive regulation of ERK1 and ERK2 cascade and biological process this GO :0071345 and cellular response to cytokine stimulus and biological process this GO :0071731 and response to nitric oxide and biological process this GO :0072610 and interleukin-12 secretion and biological process this GO :0090023 and positive regulation of neutrophil chemotaxis and biological process this GO :0097022 and lymphocyte migration into lymph node and biological process this GO :0097029 and mature dendritic cell differentiation and biological process this GO :2000107 and negative regulation of leukocyte apoptotic process and biological process this GO :2000147 and positive regulation of cell motility and biological process this GO :2000510 and positive regulation of dendritic cell chemotaxis and biological process this GO :2000522 and positive regulation of immunological synapse formation and biological process this GO :2000525 and positive regulation of T cell costimulation and biological process this GO :2000526 and positive regulation of glycoprotein biosynthetic process involved in immunological synapse formation and biological process this GO :2000547 and regulation of dendritic cell dendrite assembly and biological process, this GO :0004930 : G-protein coupled receptor activity, this GO :0004930 : G-protein coupled receptor activity and also this GO :0005515 : protein binding and also this GO :0016493 : C-C chemokine receptor activity and also this GO :0035757 : chemokine (C-C motif) ligand 19 binding and also this GO :0035758 : chemokine (C-C motif) ligand 21 binding and also this GO :0038117 : C-C motif chemokine 19 receptor activity and also this GO :0038121 : C-C motif chemokine 21 receptor activity, this GO :0005515 : protein binding, this GO :0016493 : C-C chemokine receptor activity, this GO :0035757 : chemokine (C-C motif) ligand 19 binding, this GO :0035758 : chemokine (C-C motif) ligand 21 binding, this GO :0038117 : C-C motif chemokine 19 receptor activity, this GO :0038121 : C-C motif chemokine 21 receptor activity, chemokine (C-C motif) receptor 7 |
| Identity: |
1608 |
| Gene: |
CCR7 |
More about : CCR7 |
| Long gene name: |
C-C motif chemokine receptor 7 |
| Synonyms gene: |
CMKBR7 EBI1 |
| Synonyms gene name: |
chemokine (C-C motif) receptor 7 |
| Locus: |
17q21, 2 |
| Discovery year: |
1994-05-17 |
| Entrez gene record: |
1236 |
| Pubmed identfication: |
8383238 |
| Classification: |
CD molecules C-C motif chemokine receptors |
| Havana BLAST/BLAT: |
OTTHUMG00000133375 |