| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
DUSP10/MKP5 |
| Specificity: |
This antibody reacts specifically with DUSP10/MKP5 |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Antigen Source: |
KLH conjugated synthetic peptide derived from human DUSP10/MKP5 |
| Gene ID: |
11221 |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
DSP gene expression is induced by a host of growth factors and/or cellular stresses, Dual specificity phosphatases (DSPs) are a subclass of the protein tyrosine phosphatase (PTP) gene superfamily, It is ubiquitously expressed and localizes to both the cytoplasm and the nucleus, MKP-5 has been implicated in cell proliferation and apoptosis, MKP-5 preferentially binds to p38, SAPK/JNK and p38, but also to SAPK/JNK, thereby negatively regulating MAP kinase superfamily members including MAPK/ERK, tumor invasion and immune responses, which are selective for dephosphorylating critical phosphothreonine and phosphotyrosine residues within MAP kinases, Mitogen-activated protein (MAP) kinases are a large class of proteins involved in signal transduction pathways that are activated by a range of stimuli and mediate a number of physiological and pathological changes in the cell |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
MKP-5 MKP5 |
| Also known as: |
DUSP10/MKP5 Polyclonal Antibody |
| Other name: |
Anti-DUSP10/MKP5 Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
DUSP10/MKP5 |
| Short name: |
Anti-DUSP10/MKP5 (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, antibody to-DUSP10/MKP5 (polyclonal) |
| Alternative technique: |
polyclonals |
| Identity: |
3065 |
| Gene: |
DUSP10 |
More about : DUSP10 |
| Long gene name: |
dual specificity phosphatase 10 |
| Locus: |
1q41 |
| Discovery year: |
1999-11-26 |
| GenBank acession: |
AB026436 |
| Entrez gene record: |
11221 |
| Pubmed identfication: |
10391943 10597297 |
| RefSeq identity: |
NM_007207 |
| Classification: |
MAP kinase phosphatases |
| Havana BLAST/BLAT: |
OTTHUMG00000037269 |