| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
ASPP2/p53BP2 |
| Specificity: |
This antibody reacts specifically with ASPP2/p53BP2 |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Subcellular locations: |
Nucleus, Cytoplasm |
| Antigen Source: |
KLH conjugated synthetic peptide derived from human ASPP2 |
| Gene ID: |
7159 |
| Swiss Prot: |
Q13625 |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
Impedes cell cycle progression at G2/M, Inhibits the ability of APPBP1 to conjugate NEDD8 to CUL1, Its apoptosis-stimulating activity is inhibited by its interaction with DDX42, Regulates TP53 by enhancing the DNA binding and transactivation function of TP53 on the promoters of proapoptotic genes in vivo, and thereby decreases APPBP1 ability to induce apoptosis, Regulator that plays a central role in regulation of apoptosis and cell growth via its interactions |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
PPP1R13A ASPP2 53BP2 |
| Also known as: |
ASPP2/p53BP2 Polyclonal Antibody |
| Other name: |
Anti-ASPP2/p53BP2 Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
ASPP2/p53BP2 |
| Short name: |
Anti-ASPP2/p53BP2 (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, antibody to-ASPP2/p53BP2 (polyclonal) |
| Alternative technique: |
polyclonals |
| Identity: |
12000 |
| Gene: |
TP53BP2 |
More about : TP53BP2 |
| Long gene name: |
tumor protein p53 binding protein 2 |
| Synonyms gene name: |
2 , tumor protein p53-binding protein |
| Locus: |
1q41 |
| Discovery year: |
1997-06-24 |
| GenBank acession: |
U09582 |
| Entrez gene record: |
7159 |
| Pubmed identfication: |
8668206 8016121 |
| RefSeq identity: |
NM_001031685 NM_005426 |
| Classification: |
Ankyrin repeat domain containing Protein phosphatase 1 regulatory subunits |
| Havana BLAST/BLAT: |
OTTHUMG00000037379 |