| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
Collagen II/Chondrocalcin |
| Specificity: |
This antibody reacts specifically with Collagen II/Chondrocalcin |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Antigen Source: |
KLH conjugated synthetic peptide derived from human Collagen II |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Mouse (Mus musculus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
Collagen type II is essential for the normal embryonic development of the skeleton, For these reasons it is often extremely difficult to generate with specificities to collagens, In addition, Kniest dysplasia, Langer Saldino achondrogenesis, Mutations in this gene are associated with achondrogenesis, SED congenita, Stickler syndrome type I, The development of type specific is dependent on NON DENATURED three dimensional epitopes, There are two transcripts identified for this gene, This may result in diminished reactivity of some with denatured collagen or formalin fixed, Type II collagen is a fibrillar collagen found in cartilage and the vitreous humor of the eye, a calcium binding protein that is the C propeptide of this collagen molecule, and spondyloepimetaphyseal dysplasia Strudwick type, are also associated with chondrodysplasia, chondrodysplasia, defects in processing chondrocalcin, early onset familial osteoarthritis, for linear growth and for the ability of cartilage to resist compressive forces, paraffin embedded tissues, triplet repeat that is a necessary part of the triple helical structure, Collagens are highly conserved throughout evolution and are characterized by an uninterrupted ", Glycine-X-Y" |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
AOM, COL11A3, COL2A1, COL2A1 protein, Cartilage collagen, Chondrocalcin, Col2a1, Collagen alpha 1II chain precursor, Collagen type II alpha 1 primary osteoarthritis spondyloepiphyseal dysplasia congenital, MGC131516, SEDC, alpha 1, alpha-1 type II collagen, alpha1 type II collagen, collagen, collagen alpha-1II, type II, type II collagen, Collagen II alpha 1 |
| Also known as: |
Collagen II/Chondrocalcin Antibody |
| Other name: |
Anti-Collagen II/Chondrocalcin |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Gene target: |
Collagen II/Chondrocalcin |
| Short name: |
Fluor 594, Anti-Collagen II/Chondrocalcin |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, antibody to-Collagen II/Chondrocalcin |