| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
GPR56 |
| Specificity: |
This antibody reacts specifically with GPR56 |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Subcellular locations: |
Extracellular |
| Antigen Source: |
KLH conjugated synthetic peptide derived from human GPR56 |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
Defects in the gene encoding for GPR56 can cause bilateral frontoparietal polymicrogyria (BFPP) which is characterized by disorganized cortical lamination, G-protein coupled receptor 56 (GPR56), G-protein coupled receptors mediate extracellular signals into intracellular signals (G-protein activation), GPR proteins are integral seven-pass membrane proteins with some conserved amino acid regions, GPR56 plays an important role in cell-cell interactions and is widely expressed, They respond to a great variety of signaling molecules, also designated TM7XN1 protein, also known as seven transmembrane receptors, are members of the largest protein family and play a role in many different stimulus-response pathways, contains one GPS domain, heart and thyroid gland, heptahelical receptors, including hormones, neurotransmitters and other proteins and peptides, or 7TM receptors, with highest levels detected in brain, G protein-coupled receptors (GPRs or GPCRs) |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
TM7LN4 TM7XN1 |
| Also known as: |
GPR56 Polyclonal Antibody |
| Other name: |
Anti-GPR56 Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
GPR56 |
| Short name: |
Anti-GPR56 (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, antibody to-G protein-coupled receptor 56 (polyclonal) |
| Alternative technique: |
polyclonals |
| Alternative to gene target: |
BFPP and BPPR and TM7LN4 and TM7XN1, GPR56 and IDBG-33507 and ENSG00000205336 and 9289, Gpr56 and IDBG-183010 and ENSMUSG00000031785 and 14766, Plasma membranes, extracellular matrix binding, this GO :0001525 and angiogenesis and biological process this GO :0004888 and transmembrane signaling receptor activity and molecular function this GO :0004930 and G-protein coupled receptor activity and molecular function this GO :0005518 and collagen binding and molecular function this GO :0005886 and plasma membrane and cellular component this GO :0005887 and integral component of plasma membrane and cellular component this GO :0007155 and cell adhesion and biological process this GO :0007166 and cell surface receptor signaling pathway and biological process this GO :0007186 and G-protein coupled receptor signaling pathway and biological process this GO :0007218 and neuropeptide signaling pathway and biological process this GO :0007266 and Rho protein signal transduction and biological process this GO :0007267 and cell-cell signaling and biological process this GO :0007420 and brain development and biological process this GO :0008285 and negative regulation of cell proliferation and biological process this GO :0010573 and vascular endothelial growth factor production and biological process this GO :0016020 and membrane and cellular component this GO :0016021 and integral component of membrane and cellular component this GO :0021801 and cerebral cortex radial glia guided migration and biological process this GO :0021819 and layer formation in cerebral cortex and biological process this GO :0035025 and positive regulation of Rho protein signal transduction and biological process this GO :0045785 and positive regulation of cell adhesion and biological process this GO :0050840 and extracellular matrix binding and molecular function this GO :0070062 and extracellular vesicular exosome and cellular component this GO :0070528 and protein kinase C signaling and biological process this GO :0097451 and glial limiting end-foot and cellular component this GO :2001223 and negative regulation of neuron migration and biological process, this GO :0004888 : transmembrane signaling receptor activity, this GO :0004888 : transmembrane signaling receptor activity and also this GO :0004930 : G-protein coupled receptor activity and also this GO :0005518 : collagen binding and also this GO :0050840 : extracellular matrix binding, this GO :0004930 : G-protein coupled receptor activity, this GO :0005518 : collagen binding, this GO :0050840 : extracellular matrix binding, G protein-coupled receptor 56 |
| Identity: |
4512 |
| Gene: |
ADGRG1 |
More about : ADGRG1 |
| Long gene name: |
adhesion G protein-coupled receptor G1 |
| Synonyms gene: |
GPR56 |
| Synonyms gene name: |
G protein-coupled receptor 56 |
| Locus: |
16q21 |
| Discovery year: |
1998-10-12 |
| GenBank acession: |
AJ011001 |
| Entrez gene record: |
9289 |
| Pubmed identfication: |
10049584 10100861 25713288 |
| Classification: |
Adhesion G protein-coupled receptors, subfamily G |
| Havana BLAST/BLAT: |
OTTHUMG00000176742 |