| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
CADPS2 |
| Specificity: |
This antibody reacts specifically with CADPS2 |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Antigen Source: |
KLH conjugated synthetic peptide derived from human CADPS2 |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
Both CAPS-1 and CAPS-2 are expressed primarily in the brain where they regulate the secretion of various substances, CAPS proteins help to regulate cell fate during neuronal development, CAPS-1 is thought to regulate catecholamine release from neuronal cells, Defects in the genes encoding CAPS-1 and CAPS-2 are implicated in impaired cerebral development and autism, The CAPS proteins contain a PH domain that is essential for regulation of exocytosis, Through their regulation of neurotrophin release from granule cells, as well as regulation of phospholipid binding, while CAPS-2 is thought to regulate release of both brain-derived neurotrophic factor and neurotrophin-3 from granule cells, Calcium-dependent secretion activators (CAPS-1 and CAPS-2) are calcium-binding proteins that direct neurotransmitter and neuropeptide-filled vesicles to the cell membrane for secretory granule exocytosis |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
CAPS2 |
| Also known as: |
CADPS2 Polyclonal Antibody |
| Other name: |
Anti-CADPS2 Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
CADPS2 |
| Short name: |
Anti-CADPS2 (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, antibody to-Ca+and-dependent secretion activator 2 (polyclonal) |
| Alternative technique: |
polyclonals |
| Alternative to gene target: |
CADPS2 and IDBG-38565 and ENSG00000081803 and 93664, CADPS2 and IDBG-634757 and ENSBTAG00000005110 and 519444, Cadps2 and IDBG-129779 and ENSMUSG00000017978 and 320405, Cell surfaces, metal ion binding, this GO :0005515 and protein binding and molecular function this GO :0008289 and lipid binding and molecular function this GO :0009267 and cellular response to starvation and biological process this GO :0015031 and protein transport and biological process this GO :0016023 and cytoplasmic membrane-bounded vesicle and cellular component this GO :0016082 and synaptic vesicle priming and biological process this GO :0030054 and cell junction and cellular component this GO :0030659 and cytoplasmic vesicle membrane and cellular component this GO :0031410 and cytoplasmic vesicle and cellular component this GO :0042734 and presynaptic membrane and cellular component this GO :0045211 and postsynaptic membrane and cellular component this GO :0045921 and positive regulation of exocytosis and biological process this GO :0046872 and metal ion binding and molecular function, this GO :0005515 : protein binding, this GO :0005515 : protein binding and also this GO :0008289 : lipid binding and also this GO :0046872 : metal ion binding, this GO :0008289 : lipid binding, this GO :0046872 : metal ion binding, Ca++-dependent secretion activator 2 |
| Identity: |
16018 |
| Gene: |
CADPS2 |
More about : CADPS2 |
| Long gene name: |
calcium dependent secretion activator 2 |
| Synonyms gene name: |
Ca++-dependent activator protein for secretion 2 Ca2+ dependent secretion activator 2 |
| Locus: |
7q31, 32 |
| Discovery year: |
2001-07-12 |
| Entrez gene record: |
93664 |
| RefSeq identity: |
NM_017954 |
| Classification: |
Pleckstrin homology domain containing C2 domain containing |
| Havana BLAST/BLAT: |
OTTHUMG00000157093 |