| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
CNG channel beta 1/truncated GARP |
| Specificity: |
This antibody reacts specifically with CNG channel beta 1/truncated GARP |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Subcellular locations: |
Extracellular |
| Antigen Source: |
KLH conjugated synthetic peptide derived from human truncated GARP |
| Applications: |
IF(IHC-P), FCM |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200), FCM(1:20-100) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
As their condition progresses, Defects in GARP are the cause of retinitis pigmentosa type 25 (RP25), Isoform GARP2 is a high affinity rod photoreceptor phosphodiesterase (PDE6)-binding protein that modulates its catalytic properties, It forms a subunit of cyclic nucleotide-gated (CNG) channels, Patients typically have night vision blindness and loss of midperipheral visual field, RP leads to degeneration of retinal photoreceptor cells, There are 3 isoforms produced by alternative splicing, When associated with CNGA1, in response to light-induced alteration of the levels of intracellular cGMP, it is a regulator of spontaneous activation of rod PDE6, it is involved in the regulation of ion flow into the rod photoreceptor outer segment (ROS), nonselective cation channels, thereby serving to lower rod photoreceptor 'dark noise' and allowing these sensory cells to operate at the single photon detection limit, they lose their far peripheral visual field and eventually central vision as well, which play important roles in both visual and olfactory signal transduction, Glutamic acid rich protein (GARP) is a soluble protein localized to the outer segments of the rod photoreceptor |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Also known as: |
CNG channel beta 1/truncated GARP Antibody |
| Other name: |
Anti-CNG channel beta 1/truncated GARP |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Gene target: |
CNG channel beta 1/truncated GARP |
| Short name: |
Fluor 594, Anti-CNG channel beta 1/truncated GARP |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, antibody to-CNG channel b 1/truncated GARP |
| Identity: |
4161 |
| Gene: |
LRRC32 |
More about : LRRC32 |
| Long gene name: |
leucine rich repeat containing 32 |
| Synonyms gene: |
D11S833E GARP |
| Synonyms gene name: |
glycoprotein A repetitions predominant |
| Locus: |
11q13, 5 |
| Discovery year: |
1994-12-15 |
| GenBank acession: |
Z24680 |
| Entrez gene record: |
2615 |
| Pubmed identfication: |
8180135 1543912 |
| RefSeq identity: |
NM_005512 |
| Havana BLAST/BLAT: |
OTTHUMG00000133687 |