| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
CNG4/GARP |
| Specificity: |
This antibody reacts specifically with CNG4/GARP |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Subcellular locations: |
Extracellular |
| Antigen Source: |
KLH conjugated synthetic peptide derived from human CNG4 |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
CNG channels are essential components of olfactory and visual transduction (1, CNG channels have been implicated in other areas (4-6), CNG1, CNG1 and CNG4, CNG1 is also expressed in medium-sized and small-sized arteries, CNG2, CNG2, CNG3 and CNG6 are expressed in cone receptors and may combine to form a native cGMP-activated channel (2, CNG4, CNG4, CNG4, In olfactory neurons, In rod photoreceptors, The alpha subunits consist of CNG1-3 and form functional cation channels by themselves (1, The beta subunits consist of CNG4-6 and, but rather modify the properties of channels (1, do not form functional channels, suggesting a role for CNG in the regulation of arterial blood pressure and of blood supply to different regions (4), unlike the alpha subunits, which give rise to a current in response to cGMP (1-3), which open and depolarize the cell in response to cAMP (1-3), 1 and CNG4, 1 combine to form Ca ion permeable channels, 2 have been detected in the rat pineal gland (5), 2), 2), 2), 2), 3 and CNG5 are present in GT1 cell lines and may play a role in the secretion of gonadotropin-releasing hormone (6), 3 and CNG5 form Ca2+ permeable channels, 3), Cyclic nucleotide-gated (CNG) cation channels are heteromeric complexes made up of principal alpha and modulatory beta subunits (1 |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
CNCG3L, CNCG4, CNG 4, CNG channel 4, CNG channel beta 1, CNG-4, CNG4, CNGB 1, CNGB1, CNGB1B, CNGB1_HUMAN, Cyclic nucleotide gated cation channel, Cyclic nucleotide gated cation channel 4, Cyclic nucleotide gated cation channel beta 1, Cyclic nucleotide gated cation channel gamma, Cyclic nucleotide gated cation channel modulatory subunit, Cyclic nucleotide gated channel beta 1, Cyclic nucleotide gated channel photoreceptor cGMP gated 3 gamma like, GAR1, Glutamic acid rich protein, RCNC2, RCNCb, RCNCbeta, RP45, CNCG2 |
| Also known as: |
CNG4/GARP Polyclonal Antibody |
| Other name: |
Anti-CNG4/GARP Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
CNG4/GARP |
| Short name: |
Anti-CNG4/GARP (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, antibody to-CNG4/GARP (polyclonal) |
| Alternative technique: |
polyclonals |