| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
Smad1 Ser463 |
| Specificity: |
This antibody reacts specifically with Smad1 (Ser463) |
| Modification: |
Phosphorylation |
| Modification site: |
Ser463 |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Antigen Source: |
KLH conjugated synthetic phosphopeptide derived from human Smad1 around the phosphorylation site of Ser463 |
| Gene ID: |
4086 |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
Alternatively spliced transcript variants encoding the same protein have been observed, In response to BMP ligands, SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways, The phosphorylated form of this protein forms a complex with SMAD4, This protein is a target for SMAD-specific E3 ubiquitin ligases, This protein mediates the signals of the bone morphogenetic proteins (BMPs), [provided by RefSeq], a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C, and undergoes ubiquitination and proteasome-mediated degradation, apoptosis, development and immune responses, elegans gene Sma, morphogenesis, such as SMURF1 and SMURF2, this protein can be phosphorylated and activated by the BMP receptor kinase, which are involved in a range of biological activities including cell growth, which is important for its function in the transcription regulation, The protein encoded by this gene belongs to the SMAD |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
BSP 1, BSP-1, BSP1, Dwarfin A, DwfA, JV 41, JV4 1, JV4-1, JV41, MAD homolog 1, MAD mothers against decapentaplegic homolog 1, MADH 1, MADH1, MADR1, Mad related protein 1, Mad-related protein 1, Madr 1, Mothers against DPP homolog 1, Mothers against DPP homolog 1, Mothers against decapentaplegic homolog 1, Mothers against decapentaplegic homolog 1, SMAD 1, SMAD family member 1, SMAD family member 1, SMAD mothers against DPP homolog 1 Drosophila, SMAD-1, SMAD1_HUMAN, Sma and Mad related protein 1, Smad1, Smad1 phospho Ser463, Spinal muscular atrophy distal with upper limb predominance, TGF beta signaling protein 1, Transforming growth factor beta signaling protein 1, Transforming growth factor-beta-signaling protein 1, hSMAD 1, hSMAD1, p-Smad1 Ser463, Smad1 phospho S463 |
| Also known as: |
Smad1 (Ser463) Polyclonal Antibody |
| Other name: |
Anti-Smad1 (Ser463) Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
Smad1 (Ser463) |
| Short name: |
Anti-Smad1 (Ser463) (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, antibody to-SMAD family member 1 (Ser463) (polyclonal) |
| Alternative technique: |
polyclonals |