| Category: |
Antibody |
| Concentration: |
2ml sterile DI water, 5mg/ml if reconstituted with 0 |
| Form: |
Antigen affinity purified |
| Conjugation: |
Unconjugated |
| Clone: |
Polyclonal antibody |
| Recognised antigen: |
BIK / BCL2-interacting killer |
| Host animal: |
Rabbit (Oryctolagus cuniculus) |
| Clonality: |
Polyclonal (rabbit origin) |
| Species reactivity: |
Due to limited knowledge and inability to test the antibody against all known species, Mouse (Mus musculus), Rat , we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens) |
| Tested applications: |
IHC-P, WB |
| Recommended dilutions: |
1-0, 5-1ug/ml, 5ug/ml, IHC (Paraffin): 0, Western blot: 0 |
| Notes: |
Optimal dilution of the BIK antibody should be determined by the researcher |
| Intented use: |
This BIK antibodyis to be used only for research purposes and not for diagnostics |
| Uniprot #: |
Q13323 |
| Purity: |
Antigen affinity |
| Description: |
BAD and BAX, BAK, Since the activity of this protein is suppressed in the presence of survival-promoting proteins, The protein encoded by this gene shares a critical BH3 domain with other death-promoting proteins, This gene is mapped to 22q13, and for interaction with anti-apoptotic members of the BCL2 family, and viral survival-promoting proteins, it is suggested as a likely target for anti-apoptotic proteins, such as BID, that is required for its pro-apoptotic activity, 31, Bcl-2-interacting killer is a protein that in humans is encoded by the BIK gene |
| Immunogen: |
Amino acids 1-123 of human BIK were used as the immunogen for the BIK antibody |
| Storage: |
Avoid repeated freezing and thawing, Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, aliquot and store at -20 deg, the BIK antibody may be kept for up to one month refrigerated at +4 degrees C, After reconstitution, For long-term |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24° |
| Gene target: |
BIK / BCL2-interacting killer |
| Short name: |
BIK Antibody / BCL2-interacting killer |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
BCL2-interacting killer (apoptosis-inducing) (Antibody to) / B-cell CLL/lymphoma 2-interacting killer |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
BCL2 and IDBG-4354 and ENSG00000171791 and 596, BCL2 and IDBG-645006 and ENSBTAG00000019302 and 281020, BCL2-interacting killer (apoptosis-inducing), BH domain binding, BIK and IDBG-10395 and ENSG00000100290 and 638, BIP1 and BP4 and NBK, Bcl-2 and PPP1R50, Bcl2 and IDBG-185673 and ENSMUSG00000057329 and 12043, Bik and IDBG-168304 and ENSMUSG00000016758 and 12124, Plasma membranes, alpha-beta T cell lineage commitment and biological process this GO :0043473 and pigmentation and biological process this GO :0043496 and regulation of protein homodimerization activity and biological process this GO :0043497 and regulation of protein heterodimerization activity and biological process this GO :0043524 and negative regulation of neuron apoptotic process and biological process this GO :0043565 and sequence-specific DNA binding and molecular function this GO :0043583 and ear development and biological process this GO :0045069 and regulation of viral genome replication and biological process this GO :0045087 and innate immune response and biological process this GO :0045636 and positive regulation of melanocyte differentiation and biological process this GO :0045930 and negative regulation of mitotic cell cycle and biological process this GO :0046671 and negative regulation of retinal cell programmed cell death and biological process this GO :0046902 and regulation of mitochondrial membrane permeability and biological process this GO :0046930 and pore complex and cellular component this GO :0046982 and protein heterodimerization activity and molecular function this GO :0048041 and focal adhesion assembly and biological process this GO :0048066 and developmental pigmentation and biological process this GO :0048070 and regulation of developmental pigmentation and biological process this GO :0048087 and positive regulation of developmental pigmentation and biological process this GO :0048536 and spleen development and biological process this GO :0048538 and thymus development and biological process this GO :0048545 and response to steroid hormone and biological process this GO :0048546 and digestive tract morphogenesis and biological process this GO :0048589 and developmental growth and biological process this GO :0048599 and oocyte development and biological process this GO :0048743 and positive regulation of skeletal muscle fiber development and biological process this GO :0048753 and pigment granule organization and biological process this GO :0048873 and homeostasis of number of cells within a tissue and biological process this GO :0050790 and regulation of catalytic activity and biological process this GO :0050853 and B cell receptor signaling pathway and biological process this GO :0051384 and response to glucocorticoid and biological process this GO :0051402 and neuron apoptotic process and biological process this GO :0051434 and BH3 domain binding and molecular function this GO :0051607 and defense response to virus and biological process this GO :0051721 and protein phosphatase 2A binding and molecular function this GO :0051726 and regulation of cell cycle and biological process this GO :0051881 and regulation of mitochondrial membrane potential and biological process this GO :0051902 and negative regulation of mitochondrial depolarization and biological process this GO :0051924 and regulation of calcium ion transport and biological process this GO :0055085 and transmembrane transport and biological process this GO :0070059 and intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress and biological process this GO :0071310 and cellular response to organic substance and biological process this GO :0071456 and cellular response to hypoxia and biological process this GO :0072593 and reactive oxygen species metabolic process and biological process this GO :0097192 and extrinsic apoptotic signaling pathway in absence of ligand and biological process this GO :0097193 and intrinsic apoptotic signaling pathway and biological process this GO :1900740 and positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway and biological process this GO :2000134 and negative regulation of G1/S transition of mitotic cell cycle and biological process this GO :2000811 and negative regulation of anoikis and biological process this GO :2001234 and negative regulation of apoptotic signaling pathway and biological process this GO :2001240 and negative regulation of extrinsic apoptotic signaling pathway in absence of ligand and biological process this GO :2001243 and negative regulation of intrinsic apoptotic signaling pathway and biological process this GO :2001244 and positive regulation of intrinsic apoptotic signaling pathway and biological process, leucine rich repeat containing receptor signaling pathway and biological process this GO :0040007 and growth and biological process this GO :0040018 and positive regulation of multicellular organism growth and biological process this GO :0042100 and B cell proliferation and biological process this GO :0042149 and cellular response to glucose starvation and biological process this GO :0042493 and response to drug and biological process this GO :0042542 and response to hydrogen peroxide and biological process this GO :0042802 and identical protein binding and molecular function this GO :0042803 and protein homodimerization activity and molecular function this GO :0042981 and regulation of apoptotic process and biological process this GO :0043029 and T cell homeostasis and biological process this GO :0043066 and negative regulation of apoptotic process and biological process this GO :0043067 and regulation of programmed cell death and biological process this GO :0043085 and positive regulation of catalytic activity and biological process this GO :0043209 and myelin sheath and cellular component this GO :0043375 and CD8-positive, nuclei, protein phosphatase 2A binding, this GO :0000209 and protein polyubiquitination and biological process this GO :0000902 and cell morphogenesis and biological process this GO :0001101 and response to acid and biological process this GO :0001503 and ossification and biological process this GO :0001541 and ovarian follicle development and biological process this GO :0001656 and metanephros development and biological process this GO :0001657 and ureteric bud development and biological process this GO :0001658 and branching involved in ureteric bud morphogenesis and biological process this GO :0001662 and behavioral fear response and biological process this GO :0001776 and leukocyte homeostasis and biological process this GO :0001782 and B cell homeostasis and biological process this GO :0001822 and kidney development and biological process this GO :0001836 and release of cytochrome c from mitochondria and biological process this GO :0001952 and regulation of cell-matrix adhesion and biological process this GO :0002020 and protease binding and molecular function this GO :0002260 and lymphocyte homeostasis and biological process this GO :0002320 and lymphoid progenitor cell differentiation and biological process this GO :0002326 and B cell lineage commitment and biological process this GO :0002360 and T cell lineage commitment and biological process this GO :0002520 and immune system development and biological process this GO :0002931 and response to ischemia and biological process this GO :0003014 and renal system process and biological process this GO :0005515 and protein binding and molecular function this GO :0005622 and intracellular and cellular component this GO :0005634 and nucleus and cellular component this GO :0005737 and cytoplasm and cellular component this GO :0005739 and mitochondrion and cellular component this GO :0005741 and mitochondrial outer membrane and cellular component this GO :0005783 and endoplasmic reticulum and cellular component this GO :0005789 and endoplasmic reticulum membrane and cellular component this GO :0005829 and cytosol and cellular component this GO :0006470 and protein dephosphorylation and biological process this GO :0006582 and melanin metabolic process and biological process this GO :0006808 and regulation of nitrogen utilization and biological process this GO :0006874 and cellular calcium ion homeostasis and biological process this GO :0006915 and apoptotic process and biological process this GO :0006959 and humoral immune response and biological process this GO :0006974 and cellular response to DNA damage stimulus and biological process this GO :0006979 and response to oxidative stress and biological process this GO :0007015 and actin filament organization and biological process this GO :0007409 and axonogenesis and biological process this GO :0007565 and female pregnancy and biological process this GO :0007569 and cell aging and biological process this GO :0008134 and transcription factor binding and molecular function this GO :0008283 and cell proliferation and biological process this GO :0008284 and positive regulation of cell proliferation and biological process this GO :0008285 and negative regulation of cell proliferation and biological process this GO :0008584 and male this GO nad development and biological process this GO :0008625 and extrinsic apoptotic signaling pathway via death domain receptors and biological process this GO :0008630 and intrinsic apoptotic signaling pathway in response to DNA damage and biological process this GO :0008631 and intrinsic apoptotic signaling pathway in response to oxidative stress and biological process this GO :0008637 and apoptotic mitochondrial changes and biological process this GO :0009314 and response to radiation and biological process this GO :0009636 and response to toxic substance and biological process this GO :0009791 and post-embryonic development and biological process this GO :0009887 and organ morphogenesis and biological process this GO :0010039 and response to iron ion and biological process this GO :0010224 and response to UV-B and biological process this GO :0010332 and response to gamma radiation and biological process this GO :0010468 and regulation of gene expression and biological process this GO :0010507 and negative regulation of autophagy and biological process this GO :0010523 and negative regulation of calcium ion transport into cytosol and biological process this GO :0010559 and regulation of glycoprotein biosynthetic process and biological process this GO :0014031 and mesenchymal cell development and biological process this GO :0014042 and positive regulation of neuron maturation and biological process this GO :0014911 and positive regulation of smooth muscle cell migration and biological process this GO :0015267 and channel activity and molecular function this GO :0016020 and membrane and cellular component this GO :0016049 and cell growth and biological process this GO :0016248 and channel inhibitor activity and molecular function this GO :0016337 and single organismal cell-cell adhesion and biological process this GO :0018105 and peptidyl-serine phosphorylation and biological process this GO :0018107 and peptidyl-threonine phosphorylation and biological process this GO :0019903 and protein phosphatase binding and molecular function this GO :0021747 and cochlear nucleus development and biological process this GO :0022612 and gland morphogenesis and biological process this GO :0022898 and regulation of transmembrane transporter activity and biological process this GO :0030097 and hemopoiesis and biological process this GO :0030183 and B cell differentiation and biological process this GO :0030217 and T cell differentiation and biological process this GO :0030279 and negative regulation of ossification and biological process this GO :0030307 and positive regulation of cell growth and biological process this GO :0030308 and negative regulation of cell growth and biological process this GO :0030318 and melanocyte differentiation and biological process this GO :0030336 and negative regulation of cell migration and biological process this GO :0030890 and positive regulation of B cell proliferation and biological process this GO :0031069 and hair follicle morphogenesis and biological process this GO :0031103 and axon regeneration and biological process this GO :0031625 and ubiquitin protein ligase binding and molecular function this GO :0031647 and regulation of protein stability and biological process this GO :0031965 and nuclear membrane and cellular component this GO :0031966 and mitochondrial membrane and cellular component this GO :0032469 and endoplasmic reticulum calcium ion homeostasis and biological process this GO :0032835 and glomerulus development and biological process this GO :0032848 and negative regulation of cellular pH reduction and biological process this GO :0032880 and regulation of protein localization and biological process this GO :0033033 and negative regulation of myeloid cell apoptotic process and biological process this GO :0033077 and T cell differentiation in thymus and biological process this GO :0033138 and positive regulation of peptidyl-serine phosphorylation and biological process this GO :0033689 and negative regulation of osteoblast proliferation and biological process this GO :0034097 and response to cytokine and biological process this GO :0035094 and response to nicotine and biological process this GO :0035265 and organ growth and biological process this GO :0035872 and nucleotide-binding domain, this GO :0002020 : protease binding, this GO :0002020 : protease binding and also this GO :0005515 : protein binding and also this GO :0008134 : transcription factor binding and also this GO :0015267 : channel activity and also this GO :0016248 : channel inhibitor activity and also this GO :0019903 : protein phosphatase binding and also this GO :0031625 : ubiquitin protein ligase binding and also this GO :0042802 : identical protein binding and also this GO :0042803 : protein homodimerization activity and also this GO :0043565 : sequence-specific DNA binding and also this GO :0046982 : protein heterodimerization activity and also this GO :0051434 : BH3 domain binding and also this GO :0051721 : protein phosphatase 2A binding, this GO :0005515 and protein binding and molecular function this GO :0005740 and mitochondrial envelope and cellular component this GO :0006915 and apoptotic process and biological process this GO :0007283 and spermatogenesis and biological process this GO :0008584 and male this GO nad development and biological process this GO :0008637 and apoptotic mitochondrial changes and biological process this GO :0012505 and endomembrane system and cellular component this GO :0016021 and integral component of membrane and cellular component this GO :0031966 and mitochondrial membrane and cellular component this GO :0032464 and positive regulation of protein homooli this GO merization and biological process this GO :0046982 and protein heterodimerization activity and molecular function this GO :0051400 and BH domain binding and molecular function this GO :0090200 and positive regulation of release of cytochrome c from mitochondria and biological process, this GO :0005515 : protein binding, this GO :0005515 : protein binding, this GO :0005515 : protein binding and also this GO :0046982 : protein heterodimerization activity and also this GO :0051400 : BH domain binding, this GO :0008134 : transcription factor binding, this GO :0015267 : channel activity, this GO :0016248 : channel inhibitor activity, this GO :0019903 : protein phosphatase binding, this GO :0031625 : ubiquitin protein ligase binding, this GO :0042802 : identical protein binding, this GO :0042803 : protein homodimerization activity, this GO :0043565 : sequence-specific DNA binding, this GO :0046982 : protein heterodimerization activity, this GO :0046982 : protein heterodimerization activity, this GO :0051400 : BH domain binding, this GO :0051434 : BH3 domain binding, this GO :0051721 : protein phosphatase 2A binding, B-cell CLL/lymphoma 2 |
| Identity: |
990 |
| Gene: |
BCL2 |
More about : BCL2 |
| Long gene name: |
BCL2, apoptosis regulator |
| Synonyms gene name: |
B-cell CLL/lymphoma 2 |
| Synonyms: |
Bcl-2 PPP1R50 |
| Synonyms name: |
protein phosphatase 1, regulatory subunit 50 |
| Locus: |
18q21, 33 |
| Discovery year: |
2001-06-22 |
| GenBank acession: |
M14745 |
| Entrez gene record: |
596 |
| RefSeq identity: |
NM_000633 NM_000657 |
| Classification: |
Protein phosphatase 1 regulatory subunits BCL2 family |
| Havana BLAST/BLAT: |
OTTHUMG00000132791 |
| Locus Specific Databases: |
LRG_1113 |