| Category: |
Antibody |
| Concentration: |
2ml sterile DI water, 5mg/ml if reconstituted with 0 |
| Form: |
Antigen affinity purified |
| Conjugation: |
Unconjugated |
| Clone: |
Polyclonal antibody |
| Recognised antigen: |
SDHA |
| Host animal: |
Rabbit (Oryctolagus cuniculus) |
| Clonality: |
Polyclonal (rabbit origin) |
| Species reactivity: |
Due to limited knowledge and inability to test the antibody against all known species, Mouse (Mus musculus), Rat , we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens) |
| Tested applications: |
WB |
| Recommended dilutions: |
1-0, 5ug/ml, Western blot: 0 |
| Notes: |
Optimal dilution of the SDHA antibody should be determined by the researcher |
| Intented use: |
This SDHA antibodyis to be used only for research purposes and not for diagnostics |
| Uniprot #: |
P31040 |
| Purity: |
Antigen affinity |
| Description: |
Heterozygous carriers of an SDHA mutation do not develop paragangliomas as has been seen for mutations in the other subunits, Mutations in the SDHA subunit have a distinct pathology from mutations in the SDHB/SDHC/SDHD subunits, SDHA is an acronym for succinate dehydrogenase complex subunit A, The SDHA subunit is connected to the SDHB subunit on the hydrophilic, The succinate dehydrogenase (SDH) protein complex catalyzes the oxidation of succinate (succinate + ubiquinone =>, This appears to be due to the expression of two similar SDHA genes (Types I and II) in the paraganglia system, also known as succinate dehydrogenase or succinate:ubiquinone oxidoreductase, and the integral membrane protein subunits SDHC and SDHD, and weighs 72, catalytic end of the complex, consists of 4 nuclear-encoded polypeptides, fumarate + ubiquinol), it is the only subunit to never have shown tumor suppressor behaviour, the iron sulfur protein subunit (SDHB), these are the flavoprotein subunit (SDHA), 7 kDA, Complex II of the mitochondrial respiratory chain |
| Immunogen: |
Amino acids 44-380 of human SDHA were used as the immunogen for the SDHA antibody |
| Storage: |
Avoid repeated freezing and thawing, Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, aliquot and store at -20 deg, the SDHA antibody may be kept for up to one month refrigerated at +4 degrees C, After reconstitution, For long-term |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24° |
| Gene target: |
SDHA |
| Short name: |
SDHA Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
SDHA (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
10680 |
| Gene: |
SDHA |
More about : SDHA |
| Long gene name: |
succinate dehydrogenase complex flavoprotein subunit A |
| Synonyms gene: |
SDH2 |
| Synonyms gene name: |
flavoprotein (Fp) , flavoprotein (Fp) succinate dehydrogenase complex subunit A, subunit A, succinate dehydrogenase complex |
| Synonyms: |
FP SDHF |
| Synonyms name: |
succinate dehydrogenase [ubiquinone] flavoprotein subunit flavoprotein subunit of complex II |
| Locus: |
5p15, 33 |
| Discovery year: |
1995-10-24 |
| GenBank acession: |
BC001380 |
| Entrez gene record: |
6389 |
| Pubmed identfication: |
7798181 |
| RefSeq identity: |
NM_004168 |
| Classification: |
Mitochondrial complex II: succinate dehydrogenase subunits |
| Havana BLAST/BLAT: |
OTTHUMG00000090275 |
| Locus Specific Databases: |
SDHA @ LOVD TCA Cycle Gene Mutation Database LRG_315 |