| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Mouse (Mus musculus) |
| Target Protein/Peptide: |
presenilin 1 |
| Specificity: |
This antibody reacts specifically with presenilin 1 |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Antigen Source: |
KLH conjugated synthetic peptide derived from human Presenilin-1 CTF subunit |
| Gene ID: |
5663 |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Rabbit, Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
Also, Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains), Three alternative splice variants of PSEN1 have been identified, an enzyme that cleaves APP, it is thought that the presenilins are involved in the cleavage of the Notch receptor, such that they either directly regulate gamma-secretase activity or themselves are protease enzymes, Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1, PSEN2) or the amyloid precursor protein (APP) |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
PRO2207 PSARL1 RHBDS1 |
| Also known as: |
presenilin 1 Polyclonal Antibody |
| Other name: |
Anti-presenilin 1 Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
presenilin 1 |
| Short name: |
Anti-presenilin 1 (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, antibody to-presenilin 1 (polyclonal) |
| Alternative technique: |
polyclonals |
| Identity: |
18253 |
| Gene: |
PARL |
More about : PARL |
| Long gene name: |
presenilin associated rhomboid like |
| Synonyms gene: |
PSARL |
| Synonyms gene name: |
presenilin associated, rhomboid-like |
| Synonyms name: |
rhomboid 7 homolog 1 (Drosophila) |
| Locus: |
3q27, 1 |
| Discovery year: |
2003-09-03 |
| GenBank acession: |
AF116692 |
| Entrez gene record: |
55486 |
| RefSeq identity: |
NM_018622 |
| Classification: |
Rhomboid family |
| Havana BLAST/BLAT: |
OTTHUMG00000156890 |