| Category: |
Antibody |
| Concentration: |
2ml sterile DI water, 5mg/ml if reconstituted with 0 |
| Form: |
Antigen affinity purified |
| Conjugation: |
Unconjugated |
| Clone: |
Polyclonal antibody |
| Recognised antigen: |
ADAMTS5 |
| Host animal: |
Rabbit (Oryctolagus cuniculus) |
| Clonality: |
Polyclonal (rabbit origin) |
| Species reactivity: |
Due to limited knowledge and inability to test the antibody against all known species, Mouse (Mus musculus), Rat , we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens) |
| Tested applications: |
IHC-P, WB |
| Recommended dilutions: |
5-1ug/ml, 5-1ug/ml, IHC (Paraffin): 0, Western blot: 0 |
| Notes: |
Titration of the ADAMTS5 antibody may be required due to differences in protocols and secondary/substrate sensitivity, The stated application concentrations are suggested starting amounts |
| Intented use: |
This ADAMTS5 antibodyis to be used only for research purposes and not for diagnostics |
| Uniprot #: |
Q9UNA0 |
| Purity: |
Antigen affinity |
| Description: |
5, By somatic cell hybrid analysis, Echtermeyer et al, Hurskainen et al, It is a member of the large ADAMTS family of zinc-dependent proteases, The enzyme encoded by this gene contains two C-terminal TS motifs and functions as aggrecanase to cleave aggrecan, Using mouse models, a major proteoglycan of cartilage, is an enzyme that in humans is encoded by the ADAMTS5 gene, (1999) mapped the human ADAMTS5 gene to chromosome 21, (2009) showed that Sdc4 controls a pathway that activates Adamts5 at the chondrocyte cell surface through Erk1/Erk2 activation of Mmp3, A Disintegrin-Like and Metalloproteinase with Thrombospondin Type 1 Motif |
| Immunogen: |
An amino acid sequence from the C-terminus of human ADAMTS5 (TAYLALKKKNGEYLIN) was used as the immunogen for this ADAMTS5 antibody |
| Storage: |
Avoid repeated freezing and thawing, Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, For long-term, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, aliquot and store at -20 deg, the ADAMTS5 antibody can be stored for up to one month at 4oC, After reconstitution |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24° |
| Gene target: |
ADAMTS5 |
| Short name: |
ADAMTS5 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
5 (Antibody to), ADAM metallopeptidase including thrombospondin classification 1 motif |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
5, ADAM-TS 11 and ADAM-TS 5 and ADAM-TS5 and ADAMTS-11 and ADAMTS-5 and ADAMTS11 and ADMP-2, ADAMTS5 and IDBG-1207 and ENSG00000154736 and 11096, ADAMTS5 and IDBG-630284 and ENSBTAG00000000648 and 286805, Adamts5 and IDBG-173252 and ENSMUSG00000022894 and 23794, Extracellular, this GO :0004222 and metalloendopeptidase activity and molecular function this GO :0005178 and integrin binding and molecular function this GO :0005515 and protein binding and molecular function this GO :0005576 and extracellular region and cellular component this GO :0005578 and proteinaceous extracellular matrix and cellular component this GO :0006508 and proteolysis and biological process this GO :0008237 and metallopeptidase activity and molecular function this GO :0008270 and zinc ion binding and molecular function this GO :0022617 and extracellular matrix disassembly and biological process this GO :0030198 and extracellular matrix organization and biological process this GO :0031012 and extracellular matrix and cellular component this GO :0042742 and defense response to bacterium and biological process, this GO :0004222 : metalloendopeptidase activity, this GO :0004222 : metalloendopeptidase activity and also this GO :0005178 : integrin binding and also this GO :0005515 : protein binding and also this GO :0008237 : metallopeptidase activity and also this GO :0008270 : zinc ion binding, this GO :0005178 : integrin binding, this GO :0005515 : protein binding, this GO :0008237 : metallopeptidase activity, this GO :0008270 : zinc ion binding, zinc ion binding, ADAM metallopeptidase with thrombospondin type 1 motif |
| Identity: |
221 |
| Gene: |
ADAMTS5 |
More about : ADAMTS5 |
| Long gene name: |
ADAM metallopeptidase with thrombospondin type 1 motif 5 |
| Synonyms gene name: |
5 (aggrecanase-2) , a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif |
| Synonyms: |
ADMP-2 ADAMTS11 |
| Synonyms name: |
aggrecanase-2 |
| Locus: |
21q21, 3 |
| Discovery year: |
1999-08-23 |
| GenBank acession: |
AF142099 |
| Entrez gene record: |
11096 |
| Pubmed identfication: |
10438522 |
| Classification: |
ADAM metallopeptidases with thrombospondin type 1 motif |
| Havana BLAST/BLAT: |
OTTHUMG00000078686 |