| Category: |
Antibody |
| Concentration: |
2ml sterile DI water, 5mg/ml if reconstituted with 0 |
| Form: |
Antigen affinity purified |
| Conjugation: |
Unconjugated |
| Clone: |
Polyclonal antibody |
| Recognised antigen: |
ADAMTS4 |
| Host animal: |
Rabbit (Oryctolagus cuniculus) |
| Clonality: |
Polyclonal (rabbit origin) |
| Species reactivity: |
Due to limited knowledge and inability to test the antibody against all known species, Mouse (Mus musculus), Rat , we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens) |
| Tested applications: |
WB |
| Recommended dilutions: |
5-1ug/ml, Western blot: 0 |
| Notes: |
Titration of the ADAMTS4 antibody may be required due to differences in protocols and secondary/substrate sensitivity, The stated application concentrations are suggested starting amounts |
| Intented use: |
This ADAMTS4 antibodyis to be used only for research purposes and not for diagnostics |
| Uniprot #: |
O75173 |
| Purity: |
Antigen affinity |
| Description: |
It is a member of the large ADAMTS family of zinc-dependent proteases, It is responsible for the degradation of aggrecan, The cleavage of aggrecan and brevican suggests key roles of this enzyme in arthritic disease and in the central nervous system, The enzyme encoded by this gene lacks a C-terminal TS motif, The human ADAMTS4 gene is mapped to chromosome 1 by somatic cell hybrid analysis, a brain-specific extracellular matrix protein, a major proteoglycan of cartilage, and brevican, in the progression of glioma, potentially, 'A disintegrin and metalloproteinase with thrombospondin motifs 4' is an enzyme that in humans is encoded by the ADAMTS4 gene |
| Immunogen: |
An amino acid sequence from the C-terminus of human ADAMTS4 (RRAQILEILRRRPWAGRK) was used as the immunogen for this ADAMTS4 antibody |
| Storage: |
Avoid repeated freezing and thawing, Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, For long-term, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, aliquot and store at -20 deg, the ADAMTS4 antibody can be stored for up to one month at 4oC, After reconstitution |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24° |
| Gene target: |
ADAMTS4 |
| Short name: |
ADAMTS4 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
ADAMTS4 (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
220 |
| Gene: |
ADAMTS4 |
More about : ADAMTS4 |
| Long gene name: |
ADAM metallopeptidase with thrombospondin type 1 motif 4 |
| Synonyms gene name: |
4 , a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif |
| Synonyms: |
KIAA0688 ADAMTS-2 ADMP-1 |
| Locus: |
1q23, 3 |
| Discovery year: |
1999-04-15 |
| GenBank acession: |
AB014588 |
| Entrez gene record: |
9507 |
| Pubmed identfication: |
10094461 |
| RefSeq identity: |
NM_005099 |
| Classification: |
ADAM metallopeptidases with thrombospondin type 1 motif |
| Havana BLAST/BLAT: |
OTTHUMG00000034349 |