| Category: |
Antibody |
| Concentration: |
2ml sterile DI water, 5mg/ml if reconstituted with 0 |
| Form: |
Antigen affinity purified |
| Conjugation: |
Unconjugated |
| Clone: |
Polyclonal antibody |
| Recognised antigen: |
LKB1 |
| Host animal: |
Rabbit (Oryctolagus cuniculus) |
| Clonality: |
Polyclonal (rabbit origin) |
| Species reactivity: |
Due to limited knowledge and inability to test the antibody against all known species, Mouse (Mus musculus), Rat , we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens) |
| Tested applications: |
IHC-P, WB |
| Recommended dilutions: |
5-1ug/ml, 5-1ug/ml, IHC (Paraffin): 0, Western blot: 0 |
| Notes: |
Titration of the LKB1 antibody may be required due to differences in protocols and secondary/substrate sensitivity, The stated application concentrations are suggested starting amounts |
| Intented use: |
This LKB1 antibodyis to be used only for research purposes and not for diagnostics |
| Uniprot #: |
Q15831 |
| Purity: |
Antigen affinity |
| Description: |
Jenne et al, Karuman et al, Smith et al, The STK11/LKB1 gene, regulates cell polarity and functions as a tumour suppressor Smith et al, which are transcribed in telomere-to-centromere direction, which encodes a member of the serine/threonine kinase, (1998) determined that the gene extends over 23 kb of genomic DNA and is composed of 9 exons, (1999) found that the mouse Lkb1 gene consists of 10 exons covering approximately 15 kb, (1999) found that the mouse Lkb1 gene encodes a protein showing strong sequence similarity to human protein, (2001) demonstrated that LKB1 physically associates with p53(191170) and regulates specific p53-dependent apoptosis pathways, Serine/threonine kinase 11 or LKB1 is a protein kinase which in humans is encoded by the STK11 gene |
| Immunogen: |
An amino acid sequence from the C-terminus of human STK11/LKB1 (SSKIRRLSACKQQ) was used as the immunogen for this LKB1 antibody |
| Storage: |
Avoid repeated freezing and thawing, Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, For long-term, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, aliquot and store at -20 deg, the LKB1 antibody can be stored for up to one month at 4oC, After reconstitution |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24° |
| Gene target: |
LKB1 |
| Short name: |
LKB1 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
LKB1 (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
11389 |
| Gene: |
STK11 |
More about : STK11 |
| Long gene name: |
serine/threonine kinase 11 |
| Synonyms gene name: |
serine/threonine kinase 11 (Peutz-Jeghers syndrome) |
| Synonyms: |
PJS LKB1 |
| Synonyms name: |
polarization-related protein LKB1 |
| Locus: |
19p13, 3 |
| Discovery year: |
1998-01-21 |
| GenBank acession: |
U63333 |
| Entrez gene record: |
6794 |
| Pubmed identfication: |
9425897 |
| RefSeq identity: |
NM_000455 |
| Havana BLAST/BLAT: |
OTTHUMG00000180118 |
| Locus Specific Databases: |
LRG_319 |