| Category: |
Antibody |
| Concentration: |
2ml sterile DI water, 5mg/ml if reconstituted with 0 |
| Form: |
Antigen affinity purified |
| Conjugation: |
Unconjugated |
| Clone: |
Polyclonal antibody |
| Recognised antigen: |
PMVK |
| Host animal: |
Rabbit (Oryctolagus cuniculus) |
| Clonality: |
Polyclonal (rabbit origin) |
| Species reactivity: |
Due to limited knowledge and inability to test the antibody against all known species, Mouse (Mus musculus), Rat , we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens) |
| Tested applications: |
IHC-P, WB |
| Recommended dilutions: |
5-1ug/ml, 5-1ug/ml, IHC (Paraffin): 0, Western blot: 0 |
| Notes: |
Titration of the PMVK antibody may be required due to differences in protocols and secondary/substrate sensitivity, The stated application concentrations are suggested starting amounts |
| Intented use: |
This PMVK antibodyis to be used only for research purposes and not for diagnostics |
| Uniprot #: |
Q15126 |
| Purity: |
Antigen affinity |
| Description: |
And PMKase gene expression is subject to regulation by sterol at the level of transcription, It is a single copy gene covering less than 15 kb in the human genome, It is mapped to chromosome 1p13-1q22-23 and spans more than 8, It was expressed highly in heart, PMVK is a peroxisomal protein which requires the C-terminal peroxisomal targeting signal, Ser-Arg-Leu, Ser-Arg-Leu, The human PMKase amino acid sequence contains a consensus peroxisomal targeting sequence(PTS-1), and lung, at the C terminus of the protein, for localization to the organelle, kidney and pancreas and slightly lower in brain, liver, placenta, skeletal muscle, 4 kb in the human genome, Phosphomevalonate kinase is a cytosolic enzyme that catalyzes the conversion of mevalonate-5-phosphate to mevalonate-5-diphosphate |
| Immunogen: |
An amino acid sequence from the middle region of human PMVK (EQSRQQRGWVFTPGVDD) was used as the immunogen for this PMVK antibody (100% homologous in human and mouse) |
| Storage: |
Avoid repeated freezing and thawing, Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, For long-term, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, aliquot and store at -20 deg, the PMVK antibody can be stored for up to one month at 4oC, After reconstitution |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24° |
| Gene target: |
PMVK |
| Short name: |
PMVK Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
PMVK (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
9141 |
| Gene: |
PMVK |
More about : PMVK |
| Long gene name: |
phosphomevalonate kinase |
| Synonyms: |
PMK PMKA HUMPMKI |
| Locus: |
1q21, 3 |
| Discovery year: |
1999-07-09 |
| GenBank acession: |
L77213 |
| Entrez gene record: |
10654 |
| Pubmed identfication: |
8663599 10191291 |
| RefSeq identity: |
NM_006556 |
| Havana BLAST/BLAT: |
OTTHUMG00000037415 |