| Gene info: |
A missense mutation in this protein in humans is the cause of one fo rm of hereditary severe combined immune deficiency (SCID) which results in ablated T-cell Ca++ entry, It has been suggested that ORAI1 functions as a highly selective Ca++ plasma membrane channel that is gated through interactions with STIM1, ORAI1 is a recently identified four-transmembrane spanning protein that is an essential component of CRAC, ORAI1 often migrates at a higher than expected molecular weight in SDS-PAGE, This antibody is predicted to have no cross-reactivity to ORAI2 or ORAI3, the store-activated endoplasmic reticulum Ca++ sensor, ORAI1 Monoclonal Antibody: Antigen stimulation of immune cells triggers Ca++ entry through Ca++ release-activated Ca++ (CRAC) channels |
| Gene names: |
CRACM1, ORAT1, TMEM142A, ORAI1 Antibody [6D11A11] : IMD9 |
| Antibodie's label: |
unlabelled serum |
| Purity: |
ORAI1 Monoclonal Antibody is immunoaffinity chromotography purified IgG |
| Ab raised in: |
Mouse |
| Type: |
Monoclonal |
| Monoclonal: |
6D11A11 |
| Immunoglobulin: |
IgG2b |
| Antigen: |
Mouse monoclonal ORAI1 antibody was made against a 16 amino acid synthetic peptide from near the carboxy terminus of human ORAI1 |
| Immuno application: |
Western Blot, immuno fluorescence, immuno-histo-chemistry, ELISA |
| Antibody advice: |
Antibody can also be used for immunohistochemistry starting at 2, For immunofluorescence start at 20 ug/mL, 5 ug/mL, ORAI1 antibody can be used for detection of ORAI1 by Western blot at 1 - 2 ug/mL |
| Suspention, pH, azide: |
02% sodium azide, ORAI1 Monoclonal Antibody is supplied in PBS containing 0 |
| Keep at: |
stable for one year, ORAI1 monoclonal antibody can be stored at -20 grades C |
| Works with: |
Mouse, Rat, Human |
| Omim nr: |
97180269 |
| Ncbi nr: |
Q96D31 |
| Vial with antibody: |
in solution |
| Quantity per ml: |
1 mg/mL |
| NCBI GENE nr: |
84876 |
| GENE symbol: |
ORAI1 |
| Antigene name: |
ORAI calcium release-activated calcium modulator 1 |
| Source: |
homo sapiens |
| Protein nr: |
Q96D31 |
| Description: |
Freeze thaw will destroy a percentage in every cycle and should be avoided, C in a fridge short term in a concentrated dilution, This antibody needs to be stored at + 4° |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by proscience they should be stored frozen at - 24° |
| Gene target: |
ORAI1 [6D11A11] |
| Short name: |
anti-ORAI1 Antibody [6D11A11] |
| Technique: |
antibodies against human proteins, antibodies for, antibody to, Antibody |
| Alternative name: |
antibody to-ORAI1 (Antibody to) [6D11A11] |
| Alternative technique: |
antibodies |
| Identity: |
3829 |
| Gene: |
FRA10A |
More about : FRA10A |
| Long gene name: |
folic acid type, fra(10)(q23, fragile site, rare, 2) , 3) or fra(10)(q24 |
| Locus: |
10q23, 2 , 3 or 10q24 |
| Discovery year: |
1986-01-01 |
| Pubmed identfication: |
15203205 |