| Long name: |
123) Monoclonal Antibody, 125, ATG5 (1358CT289 |
| Also known as: |
123) Monoclonal Antibody, 125, ATG5 (1358CT289 |
| Category: |
Primary Antibodies |
| Conjugation: |
Unconjugated |
| Target Antigen: |
ATG5 |
| Specificity: |
This is a highly specific antibody against ATG5 |
| Modification(s): |
None |
| Modification site(s): |
Unmodified antibody |
| Clonality: |
Monoclonal |
| Clone number: |
123, 125, 1358CT289 |
| Source: |
This ATG5 antibody is generated from a mouse immunized with a recombination protein from the human region of human ATG5 |
| Gene ID number: |
9474 |
| Swiss Prot: |
Q9H1Y0 |
| Tested Applications: |
WB |
| Recommended dilutions: |
WB(1:1000) |
| Cross reactivity: |
Mouse, Rat, Human |
| Cross reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen: |
Also plays a role in translation or delivery of incoming viral RNA to the translation apparatus, Conjugation with ATG12, Involved in mitochondrial quality control after oxidative damage, Involved in the maintenance of axon morphology and membrane structures, Its expression is a relatively late event in the apoptotic process, May play an important role in the apoptotic process, Plays a critical role in multiple aspects of lymphocyte development and is essential for both B and T lymphocyte survival and proliferation, Plays a crucial role in IFN-gamma-induced autophagic cell death by interacting with FADD, Promotes primary ciliogenesis through removal of OFD1 from centriolar satellites and degradation of IFT20 via the autophagic pathway, Required for optimal processing and presentation of antigens for MHC II, The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8 family proteins and their association to the vesicle membranes, The ATG12-ATG5 conjugate also negatively regulates the innate antiviral immune response by blocking the type I IFN production pathway through direct association with RARRES3 and MAVS, and in subsequent cellular longevity, as well as in normal adipocyte differentiation, is essential for its function, occurring downstream of caspase activity, possibly within the modified cytoskeleton, through a ubiquitin-like conjugating system involving ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, Involved in autophagic vesicle formation |
| Storage conditions: |
50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names: |
APG5, APG5-LIKE, APG5L, ATG5, Apoptosis-specific protein, Autophagy protein 5, hAPG5, ASP |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| About: |
Each murine monoclonal anibody has his own affinity specific for the clone, Mouse monoclonal antibodies are purified protein A or G and can be conjugated to FITC for flow cytometry or FACS and can be of different isotypes, Monoclonals of this antigen are available in different clones |
| Gene target: |
123) Monoclonal, 125, ATG5 (1358CT289 |
| Short name: |
123) Monoclonal Antibody, 125, ATG5 (1358CT289 |
| Technique: |
Monoclonals or monoclonal antibodies, antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
123) monoclonal (Antibody to), 125, autophagy related 5 (1358CT289 |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
APG5 and APG5-LIKE and APG5L and ASP and hAPG5, ATG5 and IDBG-631895 and ENSBTAG00000005400 and 532686, ATG5 and IDBG-94856 and ENSG00000057663 and 9474, Atg5 and IDBG-148568 and ENSMUSG00000038160 and 11793, Plasma membranes, protein binding, this GO :0000045 and autophagic vacuole assembly and biological process this GO :0001974 and blood vessel remodeling and biological process this GO :0002739 and regulation of cytokine secretion involved in immune response and biological process this GO :0005515 and protein binding and molecular function this GO :0005737 and cytoplasm and cellular component this GO :0005776 and autophagic vacuole and cellular component this GO :0005930 and axoneme and cellular component this GO :0006914 and autophagy and biological process this GO :0006915 and apoptotic process and biological process this GO :0009620 and response to fungus and biological process this GO :0016020 and membrane and cellular component this GO :0031397 and negative regulation of protein ubiquitination and biological process this GO :0032480 and negative regulation of type I interferon production and biological process this GO :0034045 and pre-autopha this GO somal structure membrane and cellular component this GO :0039689 and negative stranded viral RNA replication and biological process this GO :0042311 and vasodilation and biological process this GO :0042493 and response to drug and biological process this GO :0043066 and negative regulation of apoptotic process and biological process this GO :0043687 and post-translational protein modification and biological process this GO :0045087 and innate immune response and biological process this GO :0048840 and otolith development and biological process this GO :0055015 and ventricular cardiac muscle cell development and biological process this GO :0060047 and heart contraction and biological process this GO :1902017 and regulation of cilium assembly and biological process, this GO :0005515 : protein binding, this GO :0005515 : protein binding, autophagy related 5 |
| Identity: |
589 |
| Gene: |
ATG5 |
More about : ATG5 |
| Long gene name: |
autophagy related 5 |
| Synonyms gene: |
APG5L |
| Synonyms gene name: |
APG5 (autophagy 5, S, cerevisiae) , cerevisiae) ATG5 autophagy related 5 homolog (S, cerevisiae)-like APG5 autophagy 5-like (S |
| Synonyms: |
ASP APG5 hAPG5 |
| Locus: |
6q21 |
| Discovery year: |
1999-09-16 |
| GenBank acession: |
Y11588 |
| Entrez gene record: |
9474 |
| Pubmed identfication: |
9563500 11349150 15778222 |
| RefSeq identity: |
NM_004849 |
| Classification: |
Autophagy related |
| Havana BLAST/BLAT: |
OTTHUMG00000016193 |