| known also as: |
Anti-RABBIT ANTI ATG5-ATG12 COMPLEX (C-TERMINAL) |
| known also as: |
RABBIT ANTI ATG5-ATG12 COMPLEX (C-TERMINAL) |
| known also as: |
Lapin ANTI ATG5-ATG12 COMPLEX (C-TERMINAL) |
| known also as: |
ATG5-ATG12 COMPLEX |
| Other names: |
ATG12 autophagy related 12 homolog, Apg12 (autophagy, Autophagy-related protein 12, Ubiquitin-like protein ATG12, autophagy related 12, ubiquitin-like protein ATG12, yeast) homolog, ubiquitin-like protein ATG12 isoform 1 |
| Other gene names: |
APG12, APG12, APG12-like, APG12L, APG12L, ATG12, FBR93, HAPG12, ATG12 |
| Category: |
Antibodies |
| Clonality: |
Polyclonal |
| Immunoglobulin isotype: |
Polyclonal IgG |
| Clone: |
Polyclonal antibody |
| Host organism: |
Rabbit |
| Species reactivity: |
Mouse |
| Specificity and cross-reactivity: |
_x000D__x000D_Studies have shown that the Atg5-Atg12 complex directly interacts with RIG-1 (retinoic acid-inducible gene 1) and the adaptor molecule IPS-1 (IFN-beta promoter stimulator 1), and as a contributor to RNA viral replication within the host cells, and is emerging as an important factor in the innate immune response to viruses, thereby acting as a negative regulator of the type I IFN production pathway, through caspase recruitment domains (CARDs), which plays a key role in the regulation of autophagy, ATG5-ATG12 COMPLEX This item specifically recognises an epitope within the C-Terminal (CT) region of the Atg5-Atg12 complex, _x000D_ |
| Form/Appearance: |
Purified (Purified IgG - liquid) |
| Concentration: |
0mg/ml, IgG concentration 1 |
| Storage and shipping: |
Avoid repeated freezing and thawing as this may denature the antibody, Shelf Life: 18 months from date of dispatch, Should productone contain a precipitate we recommend microcentrifugation before use, Storage in frost-free freezers is not recommended, if preferred, or productone should be stored at -20 degrees Celsius, productone should be stored undiluted, Store at +Store productone at +4 degrees Celsius |
| Tested for:: |
Western Blot (WB) |
| Description: |
Polyclonal antibodies generally are more stable and retain their reactivity under unfavorable conditions, Polyclonal antibodies have series of advantages - larger batches can be supplied at a time, Properly used, To obtain more detailed information on productone, please, refer to the full product datasheet, the time needed for production is considerably shorter, they are inexpensive to manufacture and respectively to buy, this antibody will ensure excellent and reproducible results with guaranteed success for the applications that it is tested in, productone is a polyclonal antibody of high purity and binding affinity for the antigen that it is risen against |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, avoid cycles of freezing and thawing, please, In order to retain the quality and the affinity of productone unchanged |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by MBS Polyclonals_1 they should be stored frozen at - 24° |
| Gene target: |
ATG5-ATG12 COMPLEX |
| Short name: |
Anti-ATG5-ATG12 COMPLEX (C-TERMINAL) Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
antibody to-autophagy related 5-ATG12 aggregate (C-TERMINAL) (Antibody to) |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
APG5 and APG5-LIKE and APG5L and ASP and hAPG5, ATG5 and IDBG-631895 and ENSBTAG00000005400 and 532686, ATG5 and IDBG-94856 and ENSG00000057663 and 9474, Atg5 and IDBG-148568 and ENSMUSG00000038160 and 11793, Plasma membranes, protein binding, this GO :0000045 and autophagic vacuole assembly and biological process this GO :0001974 and blood vessel remodeling and biological process this GO :0002739 and regulation of cytokine secretion involved in immune response and biological process this GO :0005515 and protein binding and molecular function this GO :0005737 and cytoplasm and cellular component this GO :0005776 and autophagic vacuole and cellular component this GO :0005930 and axoneme and cellular component this GO :0006914 and autophagy and biological process this GO :0006915 and apoptotic process and biological process this GO :0009620 and response to fungus and biological process this GO :0016020 and membrane and cellular component this GO :0031397 and negative regulation of protein ubiquitination and biological process this GO :0032480 and negative regulation of type I interferon production and biological process this GO :0034045 and pre-autopha this GO somal structure membrane and cellular component this GO :0039689 and negative stranded viral RNA replication and biological process this GO :0042311 and vasodilation and biological process this GO :0042493 and response to drug and biological process this GO :0043066 and negative regulation of apoptotic process and biological process this GO :0043687 and post-translational protein modification and biological process this GO :0045087 and innate immune response and biological process this GO :0048840 and otolith development and biological process this GO :0055015 and ventricular cardiac muscle cell development and biological process this GO :0060047 and heart contraction and biological process this GO :1902017 and regulation of cilium assembly and biological process, this GO :0005515 : protein binding, this GO :0005515 : protein binding, autophagy related 5 |