| Long name: |
3, 3) Monoclonal Antibody, BCL6 (305CT16 |
| Also known as: |
3, 3) Monoclonal Antibody, BCL6 (305CT16 |
| Category: |
Primary Antibodies |
| Conjugation: |
Unconjugated |
| Target Antigen: |
BCL6 |
| Specificity: |
This is a highly specific antibody against BCL6 |
| Modification(s): |
None |
| Modification site(s): |
Unmodified antibody |
| Clonality: |
Monoclonal |
| Clone number: |
3, 3, 305CT16 |
| Source: |
This BCL6 antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 676-704 amino acids from the C-terminal region of human BCL6 |
| Gene ID number: |
604 |
| Swiss Prot: |
P41182 |
| Tested Applications: |
IF, WB |
| Recommended dilutions: |
IF(1:10~50), WB(1:1000~16000) |
| Cross reactivity: |
Human |
| Cross reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen: |
Also required for the establishment and maintenance of immunological memory for both T- and B-cells, An important function is to allow GC B-cells to proliferate very rapidly in response to T-cell dependent antigens and tolerate the physiological DNA breaks required for immunglobulin class switch recombination and somatic hypermutation without inducing a p53/TP53-dependent apoptotic response, Besides, Forms complexes with different corepressors and histone deacetylases to repress the transcriptional expression of different subsets of target genes, In GC B-cells, In follicular helper CD4(+) T-cells (T(FH) cells), In response to genotoxic stress, Represses its target genes by binding directly to the DNA sequence 5'-TTCCTAGAA-3' (BCL6-binding site) or indirectly by repressing the transcriptional activity of transcription factors, Suppresses macrophage proliferation through competition with STAT5 for STAT-binding motifs binding on certain target genes, T(H)2 and T(H)17 cells, also autoregulates its transcriptional expression and up-regulates, also controls neurogenesis through the alteration of the composition of NOTCH-dependent transcriptional complexes at selective NOTCH targets, apoptosis and cell cycle control, controls cell cycle arrest in GC B-cells in both p53/TP53-dependedent and -independent manners, including the recruitment of the deacetylase SIRT1 and resulting in an epigenetic silencing leading to neuronal differentiation, indirectly, inflammation, like miR155, promotes the expression of T(FH)-related genes but inhibits the differentiation of T(H)1, represses genes that function in differentiation, such as AICDA, such as CCL2 and CCND2, such as HES5, the expression of some genes important for GC reactions, through the repression of microRNAs expression, Transcriptional repressor mainly required for germinal center (GC) formation and antibody affinity maturation which has different mechanisms of action specific to the lineage and biological functions |
| Purification method: |
09% (W/V) sodium azide, Mouse monoclonal antibody supplied in crude ascites with 0 |
| Storage conditions: |
50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names: |
B-cell lymphoma 5 protein, B-cell lymphoma 6 protein, BCL-5, BCL-6, BCL6, BCL6A, LAZ3, Protein LAZ-3, ZBTB27, ZNF51, Zinc finger and BTB domain-containing protein 27, Zinc finger protein 51, BCL5 |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| About: |
Each murine monoclonal anibody has his own affinity specific for the clone, Mouse monoclonal antibodies are purified protein A or G and can be conjugated to FITC for flow cytometry or FACS and can be of different isotypes, Monoclonals of this antigen are available in different clones |
| Gene target: |
3, 3) Monoclonal, BCL6 (305CT16 |
| Short name: |
3, 3) Monoclonal Antibody, BCL6 (305CT16 |
| Technique: |
Monoclonals or monoclonal antibodies, antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
3, 3) monoclonal (Antibody to), B-cell CLL/lymphoma 6 (305CT16 |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
BCL5 and BCL6A and LAZ3 and ZBTB27 and ZNF51, BCL6 and IDBG-634562 and ENSBTAG00000001511 and 539020, BCL6 and IDBG-69349 and ENSG00000113916 and 604, Bcl6 and IDBG-149890 and ENSMUSG00000022508 and 12053, DNA-templated and biological process this GO :0006954 and inflammatory response and biological process this GO :0006974 and cellular response to DNA damage stimulus and biological process this GO :0007266 and Rho protein signal transduction and biological process this GO :0007283 and spermatogenesis and biological process this GO :0008104 and protein localization and biological process this GO :0008285 and negative regulation of cell proliferation and biological process this GO :0030036 and actin cytoskeleton organization and biological process this GO :0030183 and B cell differentiation and biological process this GO :0030308 and negative regulation of cell growth and biological process this GO :0030890 and positive regulation of B cell proliferation and biological process this GO :0031490 and chromatin DNA binding and molecular function this GO :0032319 and regulation of Rho GTPase activity and biological process this GO :0032764 and negative regulation of mast cell cytokine production and biological process this GO :0035024 and negative regulation of Rho protein signal transduction and biological process this GO :0042092 and type 2 immune response and biological process this GO :0042127 and regulation of cell proliferation and biological process this GO :0043065 and positive regulation of apoptotic process and biological process this GO :0043066 and negative regulation of apoptotic process and biological process this GO :0043380 and regulation of memory T cell differentiation and biological process this GO :0043565 and sequence-specific DNA binding and molecular function this GO :0045596 and negative regulation of cell differentiation and biological process this GO :0045629 and negative regulation of T-helper 2 cell differentiation and biological process this GO :0045892 and negative regulation of transcription, DNA-templated and biological process this GO :0046872 and metal ion binding and molecular function this GO :0048294 and negative regulation of isotype switching to IgE isotypes and biological process this GO :0048821 and erythrocyte development and biological process this GO :0050727 and regulation of inflammatory response and biological process this GO :0050776 and regulation of immune response and biological process this GO :0051272 and positive regulation of cellular component movement and biological process, metal ion binding, nuclei, this GO :0000060 and protein import into nucleus, this GO :0000977 : RNA polymerase II regulatory region sequence-specific DNA binding, this GO :0000977 : RNA polymerase II regulatory region sequence-specific DNA binding and also this GO :0001227 : RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription and also this GO :0003677 : DNA binding and also this GO :0003682 : chromatin binding and also this GO :0003700 : sequence-specific DNA binding transcription factor activity and also this GO :0005515 : protein binding and also this GO :0031490 : chromatin DNA binding and also this GO :0043565 : sequence-specific DNA binding and also this GO :0046872 : metal ion binding, this GO :0001227 : RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription, this GO :0003677 : DNA binding, this GO :0003682 : chromatin binding, this GO :0003700 : sequence-specific DNA binding transcription factor activity, this GO :0005515 : protein binding, this GO :0031490 : chromatin DNA binding, this GO :0043565 : sequence-specific DNA binding, this GO :0046872 : metal ion binding, translocation and biological process this GO :0000122 and negative regulation of transcription from RNA polymerase II promoter and biological process this GO :0000902 and cell morphogenesis and biological process this GO :0000977 and RNA polymerase II regulatory region sequence-specific DNA binding and molecular function this GO :0001227 and RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription and molecular function this GO :0001953 and negative regulation of cell-matrix adhesion and biological process this GO :0002467 and germinal center formation and biological process this GO :0002634 and regulation of germinal center formation and biological process this GO :0002829 and negative regulation of type 2 immune response and biological process this GO :0002903 and negative regulation of B cell apoptotic process and biological process this GO :0003677 and DNA binding and molecular function this GO :0003682 and chromatin binding and molecular function this GO :0003700 and sequence-specific DNA binding transcription factor activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005634 and nucleus and cellular component this GO :0005657 and replication fork and cellular component this GO :0006351 and transcription, B-cell CLL/lymphoma 6 |
| Identity: |
1001 |
| Gene: |
BCL6 |
More about : BCL6 |
| Long gene name: |
B-cell CLL/lymphoma 6 |
| Synonyms gene: |
ZNF51 |
| Synonyms gene name: |
zinc finger protein 51 |
| Synonyms: |
ZBTB27 LAZ3 BCL5 BCL6A |
| Locus: |
3q27, 3 |
| Discovery year: |
1993-04-12 |
| Entrez gene record: |
604 |
| RefSeq identity: |
NM_001706 |
| Classification: |
BTB domain containing Zinc fingers C2H2-type |
| Havana BLAST/BLAT: |
OTTHUMG00000156441 |