| Long name: |
Cy5 Conjugated, Bcl6 Polyclonal Antibody |
| Category: |
Conjugated Primary Antibodies |
| Conjugation: |
5, Cy5 |
| Host Organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Antigen: |
Bcl6 |
| Specificity: |
This is a highly specific antibody against Bcl6 |
| Modification: |
Unmodified |
| Modification site: |
None |
| Clonality: |
Polyclonal |
| Clone: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Immunogen_range: |
520-560/706 |
| Subcellular location: |
Nucleus |
| Source: |
KLH conjugated synthetic peptide derived from human Bcl6 |
| Gene ID number: |
604 |
| Swiss Prot: |
P41182 |
| Tested applications: |
IF(IHC-P) |
| Recommended dilutions: |
IF(IHC-P)(1:50-200) |
| Crossreactivity: |
Mouse, Rat, Human |
| Crossreactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Antigen background: |
Also required for the establishment and maintenance of immunological memory for both T- and B-cells, An important function is to allow GC B-cells to proliferate very rapidly in response to T-cell dependent antigens and tolerate the physiological DNA breaks required for immunglobulin class switch recombination and somatic hypermutation without inducing a p53/TP53-dependent apoptotic response, Besides, Forms complexes with different corepressors and histone deacetylases to repress the transcriptional expression of different subsets of target genes, In GC B-cells, In follicular helper CD4(+) T-cells (T(FH) cells), In response to genotoxic stress, Represses its target genes by binding directly to the DNA sequence 5'-TTCCTAGAA-3' (BCL6-binding site) or indirectly by repressing the transcriptional activity of transcription factors, Suppresses macrophage proliferation through competition with STAT5 for STAT-binding motifs binding on certain target genes, T(H)2 and T(H)17 cells, also autoregulates its transcriptional expression and up-regulates, also controls neurogenesis through the alteration of the composition of NOTCH-dependent transcriptional complexes at selective NOTCH targets, apoptosis and cell cycle control, controls cell cycle arrest in GC B-cells in both p53/TP53-dependedent and -independent manners, including the recruitment of the deacetylase SIRT1 and resulting in an epigenetic silencing leading to neuronal differentiation, indirectly, inflammation, like miR155, promotes the expression of T(FH)-related genes but inhibits the differentiation of T(H)1, represses genes that function in differentiation, such as AICDA, such as CCL2 and CCND2, such as HES5, the expression of some genes important for GC reactions, through the repression of microRNAs expression, Transcriptional repressor mainly required for germinal center (GC) formation and antibody affinity maturation which has different mechanisms of action specific to the lineage and biological functions |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store refrigerated at 2 to 8 degrees Celcius for up to 1 year, 09% sodium azide, Keep the antibody in an aqueous buffered solution containing 1% BSA |
| Excitation Emission: |
625, 650nm/670nm |
| Synonyms: |
B-cell lymphoma 5 protein, B-cell lymphoma 6 protein, BCL-5, BCL-6, BCL6, BCL6A, LAZ3, Protein LAZ-3, ZBTB27, ZNF51, Zinc finger and BTB domain-containing protein 27, Zinc finger protein 51, BCL5 |
| Properties: |
Cy5 antibodies are excited by the 650-nanometer wave of an argon laser and detected at a 670-nanometer captor, C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
Bcl6 Conjugated |
| Short name: |
Conjugated, Bcl6 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, antibody Conjugates, Antibody |
| Label: |
Cy5 |
| Alternative name: |
cyanine 5 coupled, B-cell CLL/lymphoma 6 (Antibody to) |
| Alternative technique: |
antibodies |