| Long name: |
1) Monoclonal Antibody, 12, LIN28A (55CT58 |
| Also known as: |
1) Monoclonal Antibody, 12, LIN28A (55CT58 |
| Category: |
Primary Antibodies |
| Conjugation: |
Unconjugated |
| Target Antigen: |
LIN28A |
| Specificity: |
This is a highly specific antibody against LIN28A |
| Modification(s): |
None |
| Modification site(s): |
Unmodified antibody |
| Clonality: |
Monoclonal |
| Clone number: |
1, 12, 55CT58 |
| Source: |
LIN28A recombinant protein is used to produce this monoclonal antibody |
| Gene ID number: |
79727 |
| Swiss Prot: |
Q9H9Z2 |
| Tested Applications: |
IF, IHC-P, WB |
| Recommended dilutions: |
IF(1:10~50), IHC-P(1:50~200), WB(1:200~2000) |
| Cross reactivity: |
Human |
| Cross reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen: |
ARBP/36B4 ribosomal protein mRNA and its own mRNA, Binds IGF2 mRNA, Essential for skeletal muscle differentiation program through the translational up-regulation of IGF2 expression (By similarity), Its association with the translational machinery and target mRNAs results in an increased number of initiation events per molecule of mRNA and, MYOD1 mRNA, Specifically binds miRNA precursors (pre-miRNAs), Suppressor of microRNA (miRNA) biogenesis, The repression of let-7 expression is required for normal development and contributes to maintain the pluripotent state by preventing let-7-mediated differentiation of embryonic stem cells (By similarity), This results in the terminal uridylation of target pre-miRNAs (PubMed:19703396) (PubMed:22118463) (PubMed:22898984), Uridylated pre-miRNAs fail to be processed by Dicer and undergo degradation, and recruits ZCCHC11/TUT4 uridylyltransferase, in mRNA stabilization, including that of let-7, indirectly, miR-143 and miR-200c, miR107, recognizing an 5'-GGAG-3' motif found in pre-miRNA terminal loop, Translational enhancer' that drives specific mRNAs to polysomes and increases the efficiency of protein synthesis |
| Purification method: |
This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS, 09% (W/V) sodium azide, Purified monoclonal antibody supplied in PBS with 0 |
| Storage conditions: |
50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names: |
LIN-28, LIN28, LIN28A, Protein lin-28 homolog A, ZCCHC1, Zinc finger CCHC domain-containing protein 1, lin-28A, CSDD1 |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| About: |
Each murine monoclonal anibody has his own affinity specific for the clone, Mouse monoclonal antibodies are purified protein A or G and can be conjugated to FITC for flow cytometry or FACS and can be of different isotypes, Monoclonals of this antigen are available in different clones |
| Gene target: |
1) Monoclonal, 12, LIN28A (55CT58 |
| Short name: |
1) Monoclonal Antibody, 12, LIN28A (55CT58 |
| Technique: |
Monoclonals or monoclonal antibodies, antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
1) monoclonal (Antibody to), 12, LIN28A (55CT58 |
| Alternative technique: |
antibodies |
| Identity: |
15986 |
| Gene: |
LIN28A |
More about : LIN28A |
| Long gene name: |
lin-28 homolog A |
| Synonyms gene: |
LIN28 |
| Synonyms gene name: |
elegans) , lin-28 homolog (C |
| Synonyms: |
LIN-28 FLJ12457 ZCCHC1 CSDD1 |
| Locus: |
1p36, 11 |
| Discovery year: |
2003-07-21 |
| GenBank acession: |
AF521099 |
| Entrez gene record: |
79727 |
| Pubmed identfication: |
12798299 |
| RefSeq identity: |
NM_024674 |
| Classification: |
Zinc fingers CCHC-type |
| Havana BLAST/BLAT: |
OTTHUMG00000003550 |