| Long name: |
DJ-1 (PARK7) (1D7) Monoclonal Antibody |
| Also known as: |
DJ-1 (PARK7) (1D7) Monoclonal Antibody |
| Category: |
Primary Antibodies |
| Conjugation: |
Unconjugated |
| Target Antigen: |
DJ-1 (PARK7) |
| Specificity: |
This is a highly specific antibody against DJ-1 (PARK7) |
| Modification(s): |
None |
| Modification site(s): |
Unmodified antibody |
| Clonality: |
Monoclonal |
| Clone number: |
1D7 |
| Concentration: |
1ug per 1ul |
| Source: |
Recombinant human protein purified from E, coli (HIS-DJ-1) |
| Gene ID number: |
11315 |
| Swiss Prot: |
Q99497 |
| Tested Applications: |
IF(IHC-P), IHC-P, WB |
| Recommended dilutions: |
0ug/ml), WB (1 |
| Cross reactivity: |
Human |
| Cross reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen: |
Acts on early glycation intermediates (hemithioacetals and aminocarbinols), Deglycates cysteines, Eliminates hydrogen peroxide and protects cells against hydrogen peroxide-induced cell death (PubMed:16390825), It is involved in neuroprotective mechanisms like the stabilization of NFE2L2 and PINK1 proteins, Its involvement in protein repair could also explain other unrelated functions, Plays a role in regulating expression or stability of the mitochondrial uncoupling proteins SLC25A14 and SLC25A27 in dopaminergic neurons of the substantia nigra pars compacta and attenuates the oxidative stress induced by calcium entry into the neurons via L-type channels during pacemaking (PubMed:18711745), Plays an important role in cell protection against oxidative stress and cell death acting as oxidative stress sensor and redox-sensitive chaperone and protease, PubMed:12796482, PubMed:14749723, PubMed:15502874, PubMed:16632486), PubMed:17015834, PubMed:18711745, PubMed:18711745), PubMed:19229105, PubMed:20304780, PubMed:21097510, PubMed:25416785), Regulates astrocyte inflammatory responses, Required for correct mitochondrial morphology and function as well as for autophagy of dysfunctional mitochondria (PubMed:19229105, and releases repaired proteins and lactate or glycolate, and thus reactivates these proteins by reversing glycation by glyoxals, arginines and lysines residues in proteins, for instance, functions probably related to its primary function (PubMed:17015834, male fertility as a positive regulator of androgen signaling pathway as well as cell growth and transformation through, may modulate lipid rafts-dependent endocytosis in astrocytes and neuronal cells (PubMed:23847046), preventing the formation of advanced glycation endproducts (AGE) (PubMed:25416785), respectively, the modulation of NF-kappa-B signaling pathway (PubMed:12612053, Protein deglycase that repairs methylglyoxal- and glyoxal-glycated amino acids and proteins |
| Purification method: |
Purified by Protein G |
| Storage conditions: |
50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names: |
DJ-1, HEL-S-67p, Oncogene DJ1, PARK7, Parkinson disease protein 7, Protein deglycase DJ-1, DJ1 |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| About: |
Each murine monoclonal anibody has his own affinity specific for the clone, Mouse monoclonal antibodies are purified protein A or G and can be conjugated to FITC for flow cytometry or FACS and can be of different isotypes, Monoclonals of this antigen are available in different clones |
| Gene target: |
DJ-1 (PARK7) (1D7) Monoclonal |
| Short name: |
DJ-1 (PARK7) (1D7) Monoclonal Antibody |
| Technique: |
Monoclonals or monoclonal antibodies, antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
DJ-1 (PARK7) (1D7) monoclonal (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
16369 |
| Gene: |
PARK7 |
More about : PARK7 |
| Long gene name: |
Parkinsonism associated deglycase |
| Synonyms gene name: |
Parkinson disease (autosomal recessive, early onset) 7 parkinson protein 7 |
| Synonyms: |
DJ-1 DJ1 |
| Locus: |
1p36, 23 |
| Discovery year: |
2001-08-07 |
| GenBank acession: |
D61380 |
| Entrez gene record: |
11315 |
| Pubmed identfication: |
11462174 9070310 25416785 |
| RefSeq identity: |
NM_007262 |
| Classification: |
Parkinson disease associated genes |
| Havana BLAST/BLAT: |
OTTHUMG00000001210 |
| Locus Specific Databases: |
Parkinson', s disease Mutation Database |