| Also known as: |
NBN / NBS1 / Nibrin |
| Other names: |
Cell cycle regulatory protein p95, Nibrin, Nijmegen breakage syndrome 1 (nibrin), Nijmegen breakage syndrome protein 1, cell cycle regulatory protein p95, nibrin, nibrin, p95 protein of the MRE11/RAD50 complex, nibrin |
| Category: |
Antibodies |
| Subcategory: |
Mnoclonal antibodies |
| Gene name: |
NBN |
| Other gene names: |
AT-V1, AT-V2, ATV, NBN, NBS, NBS, NBS1, NBS1, P95, P95, NBN |
| Clonality: |
Monoclonal |
| Immunoglobulin isotype: |
IgG1 |
| Clone: |
1D7 |
| Host organism: |
Mouse (Mus musculus) |
| Species reactivity: |
Due to limited knowledge and inability for testing each and every species, the reactivity of the antibody may extend to other species which are not listed hereby, Human (Homo sapiens) |
| Specificity and cross-reactivity: |
Since it is not possible to test each and every species our knowledge on the corss reactivity of the antibodies is limited, This particular antibody might cross react with speacies outside of the listed ones, The complete coding region of the human p95/NBS1 expressed in E Coli |
| Purification method: |
Protein G Purified |
| Form/Appearance: |
PBS |
| Concentration: |
1 miligram per 1 mililiter |
| Storage and shipping: |
Cycles of freezing and defrosting may denaturate the polypeptide chains of the antibodies and reduce their activity, For longer storage the antibody should be kept at -20 degrees Celsius, For short term storage keep the antibody at +4 degrees Celsius |
| Tested applications:: |
Immunoprecipitation (IP), Western Blot (WB), Immunohistochemistry (IHC - Paraffin) |
| Properties: |
Depending on the epitopes used human ELISA kits can be cross reactive to many other species, Human proteins, Mainly analyzed are human serum, Modern , cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies, human cell culture supernatants and biological samples, plasma, primarily , saliva, urine, , (Homo sapiens, C, C for long term storage and for short term at + 5°, Homo sapiens sapiens), If you buy Antibodies supplied by MBS mono they should be stored frozen at - 24°, humans , ssp |
| About: |
Each murine monoclonal anibody has his own affinity specific for the clone, Mouse monoclonal antibodies are purified protein A or G and can be conjugated to FITC for flow cytometry or FACS and can be of different isotypes, Monoclonals of this antigen are available in different clones |
| Test: |
A/J, BALB/c, Mouse are mature after 40 days for females and 55 days for males, SCID while the CD-1 is outbred as strain, The female mice are pregnant only 20 days and can give birth to 10 litters of 6-8 mice a year, Transgenic, congenic and inbread strains are known for C57BL/6, knock-out, Mouse , mice from the Mus musculus species are used for production of mouse monoclonal antibodies or mabs and as research model for humans in your lab, or |
| Latin name: |
Mus musculus |
| Gene target: |
Monoclonal [ 1D7] (IgG1) NBN / NBS1 / Nibrin |
| Short name: |
Mouse Monoclonal [clone 1D7] (IgG1) NBN / NBS1 / Nibrin Antibody |
| Technique: |
Monoclonals or monoclonal antibodies, antibodies against human proteins, antibodies for, mouses, Antibody |
| Isotype: |
IgG1 |
| Species: |
Humans, Mouses, Human |
| Alternative name: |
sapiens nibrin / NBS1 / Nibrin (Antibody to), Mouse monoclonal [clonality 1D7] (IgG1) to H |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
AT-V1 and AT-V2 and ATV and NBS and NBS1 and P95, NBN and IDBG-28009 and ENSG00000104320 and 4683, NBN and IDBG-645346 and ENSBTAG00000013225 and 522943, Nbn and IDBG-130577 and ENSMUSG00000028224 and 27354, nuclei, protein N-terminus binding, signal transduction by p53 class mediator and biological process this GO :0030870 and Mre11 complex and cellular component this GO :0031954 and positive regulation of protein autophosphorylation and biological process this GO :0032508 and DNA duplex unwinding and biological process this GO :0033674 and positive regulation of kinase activity and biological process this GO :0035861 and site of double-strand break and cellular component this GO :0042405 and nuclear inclusion body and cellular component this GO :0045190 and isotype switching and biological process this GO :0047485 and protein N-terminus binding and molecular function this GO :0050885 and neuromuscular process controlling balance and biological process this GO :0097193 and intrinsic apoptotic signaling pathway and biological process, telomeric region and cellular component this GO :0001701 and in utero embryonic development and biological process this GO :0001832 and blastocyst growth and biological process this GO :0003684 and damaged DNA binding and molecular function this GO :0004003 and ATP-dependent DNA helicase activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005634 and nucleus and cellular component this GO :0005654 and nucleoplasm and cellular component this GO :0005657 and replication fork and cellular component this GO :0005730 and nucleolus and cellular component this GO :0006281 and DNA repair and biological process this GO :0006302 and double-strand break repair and biological process this GO :0007050 and cell cycle arrest and biological process this GO :0007093 and mitotic cell cycle checkpoint and biological process this GO :0007095 and mitotic G2 DNA damage checkpoint and biological process this GO :0007126 and meiotic nuclear division and biological process this GO :0008134 and transcription factor binding and molecular function this GO :0008283 and cell proliferation and biological process this GO :0016605 and PML body and cellular component this GO :0030174 and regulation of DNA-dependent DNA replication initiation and biological process this GO :0030330 and DNA damage response, this GO :0000077 and DNA damage checkpoint and biological process this GO :0000723 and telomere maintenance and biological process this GO :0000724 and double-strand break repair via homolo this GO us recombination and biological process this GO :0000784 and nuclear chromosome, this GO :0003684 : damaged DNA binding, this GO :0003684 : damaged DNA binding and also this GO :0004003 : ATP-dependent DNA helicase activity and also this GO :0005515 : protein binding and also this GO :0008134 : transcription factor binding and also this GO :0047485 : protein N-terminus binding, this GO :0004003 : ATP-dependent DNA helicase activity, this GO :0005515 : protein binding, this GO :0008134 : transcription factor binding, this GO :0047485 : protein N-terminus binding, nibrin |
| Identity: |
7652 |
| Gene: |
NBN |
More about : NBN |
| Long gene name: |
nibrin |
| Synonyms gene: |
NBS NBS1 |
| Synonyms gene name: |
Nijmegen breakage syndrome 1 (nibrin) |
| Synonyms: |
ATV AT-V2 AT-V1 |
| Locus: |
8q21, 3 |
| Discovery year: |
1997-11-28 |
| GenBank acession: |
AF058696 |
| Entrez gene record: |
4683 |
| Pubmed identfication: |
9590181 9590180 |
| RefSeq identity: |
NM_001024688 |
| Classification: |
BRCA1 C complex MRN complex |
| Havana BLAST/BLAT: |
OTTHUMG00000153546 |
| Locus Specific Databases: |
LOVD - Leiden Open Variation Database LRG_158 |