| Also known as: |
AICAR / ATIC |
| Other names: |
5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase, 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase, 5-aminoimidazole-4-carboxamide-1-beta-D-ribonucleotide transformylase/inosinicase, AICAR formyltransferase/IMP cyclohydrolase bifunctional enzyme, AICAR transformylase, AICARFT/IMPCHASE, Bifunctional purine biosynthesis protein PURH, bifunctional purine biosynthesis protein PURH, epididymis secretory sperm binding protein Li 70p, phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase, bifunctional purine biosynthesis protein PURH |
| Category: |
Antibodies |
| Subcategory: |
Mnoclonal antibodies |
| Gene name: |
AICAR |
| Gene name synonims: |
ATIC |
| Other gene names: |
AICAR, AICARFT, ATIC, HEL-S-70p, IMPCHASE, PURH, PURH, ATIC |
| Clonality: |
Monoclonal |
| Immunoglobulin isotype: |
IgG1 |
| Clone: |
F38 P7 H9 |
| Host organism: |
Mouse (Mus musculus) |
| Species reactivity: |
Bat, Bovine, Chicken, Dog, Drosophila, Due to limited knowledge and inability for testing each and every species, Gorilla, Hamster, Horse, Human (Homo sapiens), Insect (at least 90% immunogen sequence identity), Monkey, Orangutan, Pig, Rabbit (Oryctolagus cuniculus) <, Rat (Rattus norvegicus), Xenopus, the reactivity of the antibody may extend to other species which are not listed hereby, /b>, Gibbon, Mouse (Mus musculus), Predicted Reactivity: <, b> |
| Specificity and cross-reactivity: |
ATIC has been identified as an activator of AMP-activated protein kinase (AMPK), Since it is not possible to test each and every species our knowledge on the corss reactivity of the antibodies is limited, The anti-inflammatory and neuroprotective functions of ATIC, This particular antibody might cross react with speacies outside of the listed ones, a known regulator of energy homeostasis, a ribonucleotide formyltransferase (5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase) and member of the purH family, also have implications for its use in the treatment of Alzheimer's disease, inhibitor of cell proliferation and inducer of apoptosis in cancerous cells of various origins, making ATIC a potential therapeutic agent for cancer, otherwise known as AICAR, which helps catalyze the final steps of the purine biosynthesis pathway, Recognizes ATIC |
| Purification method: |
Protein G Purified |
| Form/Appearance: |
0, Sourced in TCS, pH 7, 09% sodium azide, 4, PBS |
| Concentration: |
1 miligram per 1 mililiter |
| Storage and shipping: |
For long term storage aliquot and keep the antibody at -20 degrees Celsius, Freeze-thaw cycles should be avoided in order to retain the activity of the antibody, Store at +4 degrees Celsius for short term storage |
| Tested applications:: |
Western Blot (WB), Immunohistochemistry (IHC - Paraffin) |
| Properties: |
Depending on the epitopes used human ELISA kits can be cross reactive to many other species, Human proteins, Mainly analyzed are human serum, Modern , cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies, human cell culture supernatants and biological samples, plasma, primarily , saliva, urine, , (Homo sapiens, C, C for long term storage and for short term at + 5°, Homo sapiens sapiens), If you buy Antibodies supplied by MBS mono they should be stored frozen at - 24°, humans , ssp |
| About: |
Each murine monoclonal anibody has his own affinity specific for the clone, Mouse monoclonal antibodies are purified protein A or G and can be conjugated to FITC for flow cytometry or FACS and can be of different isotypes, Monoclonals of this antigen are available in different clones |
| Test: |
A/J, BALB/c, Mouse are mature after 40 days for females and 55 days for males, SCID while the CD-1 is outbred as strain, The female mice are pregnant only 20 days and can give birth to 10 litters of 6-8 mice a year, Transgenic, congenic and inbread strains are known for C57BL/6, knock-out, Mouse , mice from the Mus musculus species are used for production of mouse monoclonal antibodies or mabs and as research model for humans in your lab, or |
| Latin name: |
Mus musculus |
| Gene target: |
Monoclonal [ F38 P7 H9] (IgG1) AICAR / ATIC |
| Short name: |
Mouse Monoclonal [clone F38 P7 H9] (IgG1) AICAR / ATIC Antibody |
| Technique: |
Monoclonals or monoclonal antibodies, antibodies against human proteins, antibodies for, mouses, Antibody |
| Isotype: |
IgG1 |
| Species: |
Humans, Mouses, Human |
| Alternative name: |
sapiens AICAR / ATIC (Antibody to), Mouse monoclonal [clonality F38 P7 H9] (IgG1) to H |
| Alternative technique: |
antibodies |
| Identity: |
794 |
| Gene: |
ATIC |
More about : ATIC |
| Long gene name: |
5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase |
| Synonyms: |
PURH AICARFT IMPCHASE |
| Synonyms name: |
phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase |
| Locus: |
2q35 |
| Discovery year: |
1997-05-15 |
| Entrez gene record: |
471 |
| Pubmed identfication: |
8567683 9378707 |
| RefSeq identity: |
NM_004044 |
| Havana BLAST/BLAT: |
OTTHUMG00000133023 |