| Also known as: |
SIGLEC-5/SIGLEC-14 |
| Other names: |
CD33 antigen-like 2, CD33 antigen-like 2, OB-binding protein 2, Obesity-binding protein 2, Sialic acid-binding Ig-like lectin 5, obesity-binding protein 2, sialic acid binding Ig-like lectin 5, sialic acid-binding Ig-like lectin 5, sialic acid-binding immunoglobulin-like lectin 5, sialic acid-binding Ig-like lectin 5 |
| Category: |
Antibodies |
| Subcategory: |
Mnoclonal antibodies |
| Gene name: |
CD170, CD33L2, CD33L2, OB-BP2, OB-BP2, OBBP2, OBBP2, SIGLEC-5, SIGLEC5, Siglec-5, SIGLEC5 |
| Gene name synonims: |
CD170, CD33L2, CD33L2, OB-BP2, OB-BP2, OBBP2, OBBP2, SIGLEC-5, SIGLEC5, Siglec-5, SIGLEC5 |
| Other gene names: |
CD170, CD33L2, CD33L2, OB-BP2, OB-BP2, OBBP2, OBBP2, SIGLEC-5, SIGLEC5, Siglec-5, SIGLEC5 |
| Clonality: |
Monoclonal |
| Immunoglobulin isotype: |
IgG1 |
| Clone: |
1A5 |
| Host organism: |
Mouse (Mus musculus) |
| Species reactivity: |
Due to limited knowledge and inability for testing each and every species, the reactivity of the antibody may extend to other species which are not listed hereby, Human (Homo sapiens) |
| Specificity and cross-reactivity: |
Siglec-14 is a putative sialic-acid binding adhesion molecule, Siglec-5 contains an immunoreceptor tyrosine-based inhibitor motif (ITIM), Since it is not possible to test each and every species our knowledge on the corss reactivity of the antibodies is limited, Structurally, This particular antibody might cross react with speacies outside of the listed ones, _x000D__x000D_Clone 1A5, _x000D__x000D_Clone 1A5 has been show to cross react with Chimpanzee _x000D_, _x000D__x000D_Siglec-5 is highly related to the myelomonocytic-derived adhesion molecule CD33 (Siglec-3), a novel sialic-acid-binding Ig-like lectin, activated macrophages, also evident in other primate species, and cells of the monocyte/myeloid lineage, and mediates sialic-acid dependent binding to cells, and member of the Ig superfamily, and member of the Ig superfamily, and when phosphorylated, as well as acting as an inhibitory receptor in the down-regulation of cell activation, can bind to the SH2 domain of several SH2-containing phosphatases, expressed by dendritic cells (DCs), indicating partial gene conversion between these two Siglecs, is one of several Siglec-5 antibodies which also recognises human Siglec-14 (Sialic acid-binding Ig-like lectin 14) Siglec-14 shares an almost identical sequence with Siglec-5 within the first two Ig-like domains, neutrophils, otherwise known as CD170, predominantly expressed in hematopoietic tissues, which has been shown to associate with the activating adapter protein DAP12, which plays a part in the modulation of cellular responses, SIGLEC-5/SIGLEC-14 Clone 1A5 recognises human Siglec-5 (Sialic acid-binding Ig-like lectin 5) |
| Form/Appearance: |
Phycoerythrin (RPE) - lyophilised), RPE (Purified IgG conjugated to R |
| Storage and shipping: |
After reconstitution Keep the antibody refrigerated at +4 degrees Celsius, DO NOT FREEZE, If there is a precipitate in the vial we recommend you to briefly microcentrifugate it prior to use, Shelf Life: 12 months from date of reconstitution, Temperature variations in the range between +1C to +7C are tolerable, Temperature variations in the range between +1C to +7C are tolerable, the antibody is photosensitive and should be protected from light, the antibody should be stored undiluted, Prior to reconstitution Keep the antibody refrigerated at +4 degrees Celsius |
| Tested applications:: |
Flow Cytometry (FACS) |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by MBS mono they should be stored frozen at - 24° |
| Gene target: |
SIGLEC-5/SIGLEC-14:RPE |
| Short name: |
MOUSE Anti-HUMAN SIGLEC-5/SIGLEC-14:RPE Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
sapiens SIGLEC-5/SIGLEC-14:RPE (Antibody to), MOUSE antibody to-H |
| Alternative technique: |
antibodies |
| Identity: |
10874 |
| Gene: |
SIGLEC5 |
More about : SIGLEC5 |
| Long gene name: |
sialic acid binding Ig like lectin 5 |
| Synonyms gene: |
CD33L2 |
| Synonyms gene name: |
sialic acid binding Ig-like lectin 5 |
| Synonyms: |
OB-BP2 SIGLEC-5 CD170 |
| Locus: |
19q13, 41 |
| Discovery year: |
1998-12-16 |
| GenBank acession: |
U71383 |
| Entrez gene record: |
8778 |
| Pubmed identfication: |
10343116 |
| RefSeq identity: |
NM_003830 |
| Classification: |
CD molecules Sialic acid binding Ig like lectins V-set domain containing |
| Havana BLAST/BLAT: |
OTTHUMG00000165510 |