| Also known as: |
SIGLEC-7 |
| Other names: |
AIRM-1, AIRM-1, Adhesion inhibitory receptor molecule 1, CDw328, D-siglec, QA79 membrane protein, QA79 membrane protein, Sialic acid-binding Ig-like lectin 7, adhesion inhibitory receptor molecule 1, p75, sialic acid binding Ig-like lectin 7, sialic acid binding immunoglobulin-like lectin 7, sialic acid-binding Ig-like lectin 7, siglec-7, sialic acid-binding Ig-like lectin 7 isoform 1 |
| Category: |
Antibodies |
| Subcategory: |
Mnoclonal antibodies |
| Gene name: |
SIGLEC-7 |
| Other gene names: |
AIRM-1, AIRM1, AIRM1, CD328, CDw328, D-siglec, QA79, SIGLEC-7, SIGLEC19P, SIGLEC7, SIGLECP2, Siglec-7, p75, p75/AIRM1, SIGLEC7 |
| Clonality: |
Monoclonal |
| Immunoglobulin isotype: |
IgG1 |
| Clone: |
7, S7 |
| Host organism: |
Mouse (Mus musculus) |
| Species reactivity: |
Due to limited knowledge and inability for testing each and every species, the reactivity of the antibody may extend to other species which are not listed hereby, Human (Homo sapiens) |
| Specificity and cross-reactivity: |
Siglec-7 preferentially binds to glycoconjugates containing alpha-2, Since it is not possible to test each and every species our knowledge on the corss reactivity of the antibodies is limited, This particular antibody might cross react with speacies outside of the listed ones, _x000D__x000D_Classed as a CD33-related Siglec, _x000D__x000D_Clone S7, a putative adhesion molecule and member of the Ig superfamily, and a small population of CD8+ memory T cells, and acts as a novel inhibitory receptor for NK cells, and also at lower levels by monocytes, and hematopoiesis, and implicated in the regulation of NK cell and T cell activation, granulocytes, mediating the inhibition of NK cell cytotoxicity, monocyte-derived macrophages and dendritic cells, otherwise known as CD328, predominantly expressed by both resting and activated natural killer (NK) cells, /strong>, 3- or alpha-2, 6-linked sialic acid, 7 <, 7 is a blocking antibody_x000D__x000D__x000D__x000D__x000D__x000D__x000D_, Mouse anti Human Siglec-7 clone S7, SIGLEC-7 <, specifically recognises human Sialic acid-binding Ig-like lectin 7, strong> |
| Form/Appearance: |
FITC (Purified IgG conjugated to Fluorescein Isothiocyanate Isomer 1 (FITC) - liquid) |
| Concentration: |
1 miligram per 1 mililiter, IgG concentration 0 |
| Storage and shipping: |
If there is a precipitate in the vial we recommend you to briefly microcentrifugate it prior to use, Repeated freeze - thaw cycles may denature the peptide chains of the antibody and therefore should be maximally avoided, Shelf Life: 18 months from date of dispatch, the antibody is photosensitive and should be protected from light, the antibody should be stored undiluted, Storage in frost-free freezers is not recommended, Store the antibody at +4 degrees Celsius for short-term storage and at -20 degrees Celsius for long-term |
| Tested applications:: |
Flow Cytometry (FACS) |
| Properties: |
FITC has a green emission that's usually collected at 530 nanometers, FITC has a high quantum yield (efficiency of energy transfer from absorption to emission fluorescence) and approximately half of the absorbed photons are emitted as fluorescent light, For fluorescent microscopy applications, MBS mono FITC is highly sensitive to pH extremes, This MBS mono Fluorescein isothiocyanate (FITC) antibody is currently after some BD antibodies the most commonly used fluorescent dye for FACS, When excited at 488 nanometers, its photo bleaching effects are not observed due to a very brief interaction at the laser intercept, the 1 FITC is seldom used as it photo bleaches rather quickly though in flow cytometry applications, the FL1 detector of a FACSCalibur or FACScan, C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by MBS mono they should be stored frozen at - 24° |
| Conjugation: |
Anti-FITC Antibody |
| Gene target: |
SIGLEC-7: |
| Short name: |
MOUSE Anti-HUMAN SIGLEC-7:FITC Antibody |
| Technique: |
Fluorescein, antibodies against human proteins, antibodies for, Antibody |
| Label: |
FITC |
| Alternative name: |
sapiens SIGLEC-7:fluorecein (Antibody to), MOUSE antibody to-H |
| Alternative technique: |
antibodies |
| Identity: |
10876 |
| Gene: |
SIGLEC7 |
More about : SIGLEC7 |
| Long gene name: |
sialic acid binding Ig like lectin 7 |
| Synonyms gene: |
SIGLEC19P SIGLECP2 |
| Synonyms gene name: |
pseudogene 2 sialic acid binding Ig-like lectin 7 , pseudogene sialic acid binding Ig-like lectin, sialic acid binding Ig-like lectin 19 |
| Synonyms: |
SIGLEC-7 p75/AIRM1 QA79 CD328 |
| Locus: |
19q13, 41 |
| Discovery year: |
2000-01-26 |
| GenBank acession: |
AF170485 |
| Entrez gene record: |
27036 |
| Pubmed identfication: |
10567377 |
| RefSeq identity: |
NM_016543 |
| Classification: |
CD molecules Sialic acid binding Ig like lectins V-set domain containing |
| Havana BLAST/BLAT: |
OTTHUMG00000182895 |