| Also known as: |
CD279 |
| Other names: |
N/A, Programmed cell death protein 1, programmed cell death 1, programmed cell death protein 1, protein PD-1, programmed cell death protein 1 |
| Category: |
Antibodies |
| Subcategory: |
Mnoclonal antibodies |
| Gene name: |
CD279 |
| Other gene names: |
CD279, PD-1, PD1, PD1, PDCD1, Protein PD-1, SLEB2, hPD-1, hPD-1, hPD-l, PDCD1 |
| Clonality: |
Monoclonal |
| Immunoglobulin isotype: |
IgG2b |
| Clone: |
4F12 |
| Host organism: |
Mouse (Mus musculus) |
| Species reactivity: |
Due to limited knowledge and inability for testing each and every species, the reactivity of the antibody may extend to other species which are not listed hereby, Human (Homo sapiens) |
| Specificity and cross-reactivity: |
CD279 is associated with regulating peripheral tolerance of T cells and preventing autoimmunity and autoimmune diseases, Since it is not possible to test each and every species our knowledge on the corss reactivity of the antibodies is limited, This particular antibody might cross react with speacies outside of the listed ones, _x000D__x000D_CD279 is an immunoinhibitory receptor which interacts with its ligands CD274 (PD-L1) and CD273 (PD-L2) to inhibit the activation and proliferation of T and B cells, a type I transmembrane glycoprotein and member of the Ig superfamily, including type I diabetes and rheumatoid arthritis, otherwise known as PD-1/PDCD1, which acts as a co-stimulatory molecule and negative regulator of T-cell activation, CD279 This item specifically recognises human CD279 |
| Form/Appearance: |
Purified (Purified IgG - liquid) |
| Concentration: |
0 mg/ml, IgG concentration 1 |
| Storage and shipping: |
If there is a precipitate in the vial we recommend you to briefly microcentrifugate it prior to use, Repeated freeze - thaw cycles may denature the peptide chains of the antibody and therefore should be maximally avoided, Shelf Life: 18 months from date of dispatch, the antibody should be stored undiluted, Storage in frost-free freezers is not recommended, Store the antibody at +4 degrees Celsius for short-term storage and at -20 degrees Celsius for long-term |
| Tested applications:: |
ELISA (EIA), Western Blot (WB) |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by MBS mono they should be stored frozen at - 24° |
| Gene target: |
CD279 |
| Short name: |
MOUSE Anti-HUMAN CD279 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
sapiens CD279 (Antibody to), MOUSE antibody to-H |
| Alternative technique: |
antibodies |
| Identity: |
8760 |
| Gene: |
PDCD1 |
More about : PDCD1 |
| Long gene name: |
programmed cell death 1 |
| Synonyms gene: |
SLEB2 |
| Synonyms gene name: |
systemic lupus erythematosus susceptibility 2 |
| Synonyms: |
CD279 PD1 hSLE1 PD-1 |
| Locus: |
2q37, 3 |
| Discovery year: |
1994-05-24 |
| GenBank acession: |
AY206416 |
| Entrez gene record: |
5133 |
| Pubmed identfication: |
7851902 12402038 |
| RefSeq identity: |
NM_005018 |
| Classification: |
CD molecules V-set domain containing |
| Havana BLAST/BLAT: |
OTTHUMG00000151342 |