| Also known as: |
CD279 |
| Other names: |
N/A, Programmed cell death protein 1, mPD-1, programmed cell death 1, programmed cell death protein 1, protein PD-1, programmed cell death protein 1 |
| Category: |
Antibodies |
| Subcategory: |
Mnoclonal antibodies |
| Gene name: |
CD279 |
| Other gene names: |
Ly101, PD-1, Pd1, Pdc1, Pdcd1, Protein PD-1, mPD-1, Pdcd1 |
| Clonality: |
Monoclonal |
| Immunoglobulin isotype: |
IgG2a |
| Clone: |
RMP1-14 |
| Host organism: |
Rat (Rattus norvegicus) |
| Species reactivity: |
Due to limited knowledge and inability for testing each and every species, the reactivity of the antibody may extend to other species which are not listed hereby, Mouse (Mus musculus) |
| Specificity and cross-reactivity: |
Antibodies produced by clone RMP1-14 have been reported to block the binding of both B7-H1-Ig and B7-DC-Ig fusion proteins to PD-1 transfected BHK cells, B7-H1 (PD-L1) and B7-DC (PD-L2), CD279 is expressed predominantly on activated T- and B- lymphocytes and on a subset of thymocytes, Since it is not possible to test each and every species our knowledge on the corss reactivity of the antibodies is limited, Studies suggest that CD279, This particular antibody might cross react with speacies outside of the listed ones, Two members of the B7 family, a 55kD cell surface protein which is a member of the CD28/CTLA-4 family, an immunoinhibitory receptor, have been identified as the ligands for CD279, otherwise known as programmed death-1 (PD-1), plays a critical role in peripheral tolerance induction and prevention of autoimmune disease, CD279 This item recognises mouse CD279 |
| Form/Appearance: |
Purified (Purified IgG - liquid) |
| Concentration: |
0 mg/ml, IgG concentration 1 |
| Storage and shipping: |
If there is a precipitate in the vial we recommend you to briefly microcentrifugate it prior to use, Repeated freeze - thaw cycles may denature the peptide chains of the antibody and therefore should be maximally avoided, Shelf Life: 18 months from date of dispatch, the antibody should be stored undiluted, Storage in frost-free freezers is not recommended, Store the antibody at +4 degrees Celsius for short-term storage and at -20 degrees Celsius for long-term |
| Tested applications:: |
Immunohistology - Frozen (IHC), Flow Cytometry (FACS) |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by MBS mono they should be stored frozen at - 24° |
| Gene target: |
CD279 |
| Short name: |
RAT ANTI MOUSE CD279 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
RAT antibody to MOUSE CD279 (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
8760 |
| Gene: |
PDCD1 |
More about : PDCD1 |
| Long gene name: |
programmed cell death 1 |
| Synonyms gene: |
SLEB2 |
| Synonyms gene name: |
systemic lupus erythematosus susceptibility 2 |
| Synonyms: |
CD279 PD1 hSLE1 PD-1 |
| Locus: |
2q37, 3 |
| Discovery year: |
1994-05-24 |
| GenBank acession: |
AY206416 |
| Entrez gene record: |
5133 |
| Pubmed identfication: |
7851902 12402038 |
| RefSeq identity: |
NM_005018 |
| Classification: |
CD molecules V-set domain containing |
| Havana BLAST/BLAT: |
OTTHUMG00000151342 |