| Also known as: |
CD279 |
| Other names: |
N/A, Programmed cell death protein 1, programmed cell death 1, programmed cell death protein 1, protein PD-1, programmed cell death protein 1 |
| Category: |
Antibodies |
| Subcategory: |
Mnoclonal antibodies |
| Gene name: |
CD279 |
| Other gene names: |
CD279, PD-1, PD1, PD1, PDCD1, Protein PD-1, SLEB2, hPD-1, hPD-1, hPD-l, PDCD1 |
| Clonality: |
Monoclonal |
| Immunoglobulin isotype: |
IgG1 |
| Clone: |
MIH4 |
| Host organism: |
Mouse (Mus musculus) |
| Species reactivity: |
Due to limited knowledge and inability for testing each and every species, the reactivity of the antibody may extend to other species which are not listed hereby, Human (Homo sapiens) |
| Specificity and cross-reactivity: |
B-cells, CD274 (PD-L1) and CD273 (PD-L2), CD279 has two specific ligands, CD279 is 50-55kD membrane protein which is a member of the CD28 family, CD279 is inducibly expressed by T-cells, NK-T-cells and monocytes upon activation, Recent studies suggest that CD279 could be targeted therapeutically in the treatment of HIV infection to reduce T-cell exhaustion, Since it is not possible to test each and every species our knowledge on the corss reactivity of the antibodies is limited, This particular antibody might cross react with speacies outside of the listed ones, _x000D__x000D_Loss of CD279 function has been associated with a number of autoimmune diseases, a co-stimulatory molecule also known as programmed cell death-1 (PD-1), and functions mainly as a negative regulator of T-cell activation, and their interaction is key in the balance between stimulatory and inhibitory signals needed for effective immune responses to microbes and self-tolerance, including rheumatoid arthritis, type I diabetes and ankylosing spondylitis, CD279 This item detects CD279 |
| Form/Appearance: |
Purified (Purified IgG - liquid) |
| Concentration: |
0mg/ml, IgG concentration 1 |
| Storage and shipping: |
If there is a precipitate in the vial we recommend you to briefly microcentrifugate it prior to use, Repeated freeze - thaw cycles may denature the peptide chains of the antibody and therefore should be maximally avoided, Shelf Life: 18 months from date of dispatch, the antibody should be stored undiluted, Storage in frost-free freezers is not recommended, Store the antibody at +4 degrees Celsius for short-term storage and at -20 degrees Celsius for long-term |
| Tested applications:: |
Flow Cytometry (FACS), Immunohistology - Frozen (IHC) |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by MBS mono they should be stored frozen at - 24° |
| Gene target: |
CD279 |
| Short name: |
MOUSE Anti-HUMAN CD279 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
sapiens CD279 (Antibody to), MOUSE antibody to-H |
| Alternative technique: |
antibodies |
| Identity: |
8760 |
| Gene: |
PDCD1 |
More about : PDCD1 |
| Long gene name: |
programmed cell death 1 |
| Synonyms gene: |
SLEB2 |
| Synonyms gene name: |
systemic lupus erythematosus susceptibility 2 |
| Synonyms: |
CD279 PD1 hSLE1 PD-1 |
| Locus: |
2q37, 3 |
| Discovery year: |
1994-05-24 |
| GenBank acession: |
AY206416 |
| Entrez gene record: |
5133 |
| Pubmed identfication: |
7851902 12402038 |
| RefSeq identity: |
NM_005018 |
| Classification: |
CD molecules V-set domain containing |
| Havana BLAST/BLAT: |
OTTHUMG00000151342 |