| Also known as: |
CD275 |
| Other names: |
B7 homolog 2, B7 homolog 2, B7 homologue 2, B7-H2, B7-like protein Gl50, B7-like protein Gl50, B7-related protein 1, B7-related protein 1, ICOS ligand, ICOS ligand, inducible T-cell co-stimulator ligand, transmembrane protein B7-H2 ICOS ligand, ICOS ligand |
| Category: |
Antibodies |
| Subcategory: |
Mnoclonal antibodies |
| Gene name: |
CD275 |
| Other gene names: |
B7-H2, B7-H2, B7H2, B7H2, B7RP-1, B7RP-1, B7RP1, B7RP1, CD275, GL50, ICOS-L, ICOSL, ICOSL, ICOSLG, KIAA0653, LICOS, ICOSLG |
| Clonality: |
Monoclonal |
| Immunoglobulin isotype: |
IgG1 |
| Clone: |
MIH11 |
| Host organism: |
Mouse (Mus musculus) |
| Species reactivity: |
Due to limited knowledge and inability for testing each and every species, the reactivity of the antibody may extend to other species which are not listed hereby, Human (Homo sapiens) |
| Specificity and cross-reactivity: |
CD275 has an important physiological role in the reactivation of effector/memory T cells on the endothelium, CD275 is a member of the B7 family, Since it is not possible to test each and every species our knowledge on the corss reactivity of the antibodies is limited, This particular antibody might cross react with speacies outside of the listed ones, _x000D__x000D_CD275 is expressed on activated B-cells, _x000D__x000D_MIH11 is reported to partially block the interaction between CD275 and CD278, _x000D__x000D_The CD278-CD275 pathway is thought to be critical in the immune response to transplants, allergies and autoimmune diseases, also known as ICOS ligand (inducible T cell co-stimulator ligand), and interaction with its receptor CD278 (ICOS) plays an important role in T cell co-stimulation and inflammatory immune reactions, epithelial cells and muscle cells, monocytes and dendritic cells and is also induced on non-lymphoid tissue cells such as endothelial cells, thus controlling entry of immune cells into inflamed tissue, CD275 This item detects CD275 |
| Form/Appearance: |
Purified (Purified IgG - liquid) |
| Concentration: |
0mg/ml, IgG concentration 1 |
| Storage and shipping: |
If there is a precipitate in the vial we recommend you to briefly microcentrifugate it prior to use, Repeated freeze - thaw cycles may denature the peptide chains of the antibody and therefore should be maximally avoided, Shelf Life: 18 months from date of dispatch, the antibody should be stored undiluted, Storage in frost-free freezers is not recommended, Store the antibody at +4 degrees Celsius for short-term storage and at -20 degrees Celsius for long-term |
| Tested applications:: |
Flow Cytometry (FACS), Immunohistology - Frozen (IHC) |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by MBS mono they should be stored frozen at - 24° |
| Gene target: |
CD275 |
| Short name: |
MOUSE Anti-HUMAN CD275 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
sapiens CD275 (Antibody to), MOUSE antibody to-H |
| Alternative technique: |
antibodies |
| Identity: |
17087 |
| Gene: |
ICOSLG |
More about : ICOSLG |
| Long gene name: |
inducible T-cell costimulator ligand |
| Synonyms gene: |
ICOSL |
| Synonyms: |
KIAA0653 GL50 B7-H2 B7RP-1 B7H2 B7RP1 ICOS-L CD275 |
| Synonyms name: |
B7-related protein 1 B7 homologue 2 B7 homolog 2 |
| Locus: |
21q22, 3 |
| Discovery year: |
2003-12-12 |
| GenBank acession: |
AB014553 |
| Entrez gene record: |
23308 |
| Pubmed identfication: |
9734811 11007762 |
| RefSeq identity: |
NM_015259 |
| Classification: |
Endogenous ligands C2-set domain containing CD molecules V-set domain containing |
| Havana BLAST/BLAT: |
OTTHUMG00000086920 |