| Also known as: |
DECTIN-1 |
| Other names: |
Beta-glucan receptor, C-type (calcium dependent, C-type lectin domain family 7, C-type lectin domain family 7 member A, C-type lectin domain family 7 member A, C-type lectin superfamily member 12, C-type lectin superfamily member 12, DC-associated C-type lectin 1, Dendritic cell-associated C-type lectin 1, beta-glucan receptor, carbohydrate recognition domain) lectin, dectin-1, dendritic cell-associated C-type lectin 1, member a, superfamily member 12, C-type lectin domain family 7 member A |
| Category: |
Antibodies |
| Subcategory: |
Mnoclonal antibodies |
| Gene name: |
BGR, Bgr, Clec7a, Clecsf12, Clecsf12, DC-associated C-type lectin 1, Dectin-1, Dectin1, beta-GR, Clec7a |
| Gene name synonims: |
BGR, Bgr, Clec7a, Clecsf12, Clecsf12, DC-associated C-type lectin 1, Dectin-1, Dectin1, beta-GR, Clec7a |
| Other gene names: |
BGR, Bgr, Clec7a, Clecsf12, Clecsf12, DC-associated C-type lectin 1, Dectin-1, Dectin1, beta-GR, Clec7a |
| Clonality: |
Monoclonal |
| Immunoglobulin isotype: |
IgG2b |
| Clone: |
2A11 |
| Host organism: |
Rat (Rattus norvegicus) |
| Species reactivity: |
Due to limited knowledge and inability for testing each and every species, the reactivity of the antibody may extend to other species which are not listed hereby, Mouse (Mus musculus) |
| Specificity and cross-reactivity: |
Since it is not possible to test each and every species our knowledge on the corss reactivity of the antibodies is limited, This particular antibody might cross react with speacies outside of the listed ones, _x000D__x000D_As a major leucocyte receptor for beta-glucan this molecule may have a key role in the immunomodulatory effects of beta-glucans and in the host response to fungal pathogens, _x000D__x000D_Recent work has shown that Dectin-1 may stimulate reactive oxygen production in macropahges via the protein tyrosine kinase known as Syk, _x000D__x000D_This antibody inhibits the binding of zymosan to macrophages via the beta-glucan receptor, also known as Dectin-1, but also at lower levels by dendritic cells and a subpopulation of T cells, DECTIN-1 Recognises murine beta-glucan receptor, _x000D_Dectin-1 is predominantly expressed by cells of the monocyte/macrophage and neutrophil lineages |
| Form/Appearance: |
Biotin (Purified IgG conjugated to Biotin - liquid) |
| Concentration: |
1 miligram per 1 mililiter, IgG concentration 0 |
| Storage and shipping: |
If there is a precipitate in the vial we recommend you to briefly microcentrifugate it prior to use, Repeated freeze - thaw cycles may denature the peptide chains of the antibody and therefore should be maximally avoided, Shelf Life: 18 months from date of dispatch, Storage in frost-free freezers is not recommended, the antibody is photosensitive and should be protected from light, the antibody should be stored undiluted, Store the antibody at +4 degrees Celsius for short-term storage and at -20 degrees Celsius for long-term |
| Tested applications:: |
Flow Cytometry (FACS) |
| Properties: |
Avidin and Streptavidin bind to the small biotin and are couple to HRP or AP for ELISA, Biotin conjugates can be detected by horseradish peroxidase, To break the streptavidin Biotin bond we suggest to use a 6 molar guanidine HCl solution with acidity of pH 1, alkaline phosphatase substrates or anti biotin conjugated antibodies, 6, C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by MBS mono they should be stored frozen at - 24° |
| Conjugation: |
Biotinylated |
| Gene target: |
DECTIN-1: |
| Short name: |
RAT ANTI MOUSE DECTIN-1: Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Label: |
Biotin |
| Alternative name: |
RAT antibody to MOUSE DECTIN-1:biotinilated (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
14558 |
| Gene: |
CLEC7A |
More about : CLEC7A |
| Long gene name: |
C-type lectin domain family 7 member A |
| Synonyms gene: |
CLECSF12 |
| Synonyms gene name: |
C-type (calcium dependent, carbohydrate-recognition domain) lectin, member A , superfamily member 12 C-type lectin domain family 7 |
| Synonyms: |
dectin-1 hDectin-1 CD369 SCARE2 |
| Locus: |
12p13, 2 |
| Discovery year: |
2001-02-01 |
| GenBank acession: |
AY009090 |
| Entrez gene record: |
64581 |
| RefSeq identity: |
NM_197954 |
| Classification: |
CD molecules Scavenger receptors C-type lectin domain family |
| Havana BLAST/BLAT: |
OTTHUMG00000133597 |
| Locus Specific Databases: |
LRG_179 |