| Also known as: |
CD169 |
| Other names: |
Sialic acid-binding Ig-like lectin 1, Sialoadhesin, sialic acid binding Ig-like lectin 1, sialic acid-binding Ig-like lectin 1, sialic acid-binding immunoglobulin-like lectin 1, sialoadhesin, sialoadhesin, sialoadhesin |
| Category: |
Antibodies |
| Subcategory: |
Mnoclonal antibodies |
| Gene name: |
CD169 |
| Other gene names: |
CD169, SIGLEC-1, SIGLEC1, SN, SN, Siglec-1, dJ1009E24, 1, SIGLEC1 |
| Clonality: |
Monoclonal |
| Immunoglobulin isotype: |
IgG1 |
| Clone: |
7-239 |
| Host organism: |
Mouse (Mus musculus) |
| Species reactivity: |
Due to limited knowledge and inability for testing each and every species, the reactivity of the antibody may extend to other species which are not listed hereby, Human (Homo sapiens) |
| Specificity and cross-reactivity: |
CD169 is highly expressed by dendritic cells and on stromal macrophages in the spleen, NK cells, Since it is not possible to test each and every species our knowledge on the corss reactivity of the antibodies is limited, This particular antibody might cross react with speacies outside of the listed ones, _x000D__x000D_CD169 is a macrophage-restricted interaction molecule which binds to sialylated ligands on haematopoietic cells, _x000D__x000D_Clone 7-239 completely inhibits erythrocyte rosetting around Sn+ transductants, a subset of CD8+ T cells and B cells, a type I transmembrane glycoprotein and prototypic member of the Siglec (sialic acid binding Ig-like lectin) family, and studies have shown high expression of CD169 on macrophages in the inflammatory conditions rheumatoid arthritis and atherosclerosis, bone marrow and lymph nodes and to a lesser extent in liver, designated Siglec-1, including neutrophils, lungs and gut, monocytes, otherwise known as Sialoadhesin (Sn), through recognition of sialic acid in the alpha-2, 3- glycosidic linkage, CD169 This item specifically recognises human CD169 |
| Form/Appearance: |
Purified (Purified IgG - liquid) |
| Concentration: |
0mg/ml, IgG concentration 1 |
| Storage and shipping: |
If there is a precipitate in the vial we recommend you to briefly microcentrifugate it prior to use, Repeated freeze - thaw cycles may denature the peptide chains of the antibody and therefore should be maximally avoided, Shelf Life: 18 months from date of dispatch, the antibody should be stored undiluted, Storage in frost-free freezers is not recommended, Store the antibody at +4 degrees Celsius for short-term storage and at -20 degrees Celsius for long-term |
| Tested applications:: |
Immunohistology - Frozen (IHC), Immunoprecipitation (IP), Flow Cytometry (FACS) |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by MBS mono they should be stored frozen at - 24° |
| Gene target: |
CD169 |
| Short name: |
MOUSE Anti-HUMAN CD169 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
sapiens CD169 (Antibody to), MOUSE antibody to-H |
| Alternative technique: |
antibodies |
| Identity: |
11127 |
| Gene: |
SIGLEC1 |
More about : SIGLEC1 |
| Long gene name: |
sialic acid binding Ig like lectin 1 |
| Synonyms gene: |
SN |
| Synonyms gene name: |
sialoadhesin , sialoadhesin sialic acid binding Ig-like lectin 1 |
| Synonyms: |
SIGLEC-1 CD169 FLJ00051 FLJ00055 FLJ00073 FLJ32150 dJ1009E24, 1 sialoadhesin |
| Locus: |
20p13 |
| Discovery year: |
1995-03-15 |
| GenBank acession: |
AF230073 |
| Entrez gene record: |
6614 |
| Pubmed identfication: |
8530048 |
| RefSeq identity: |
NM_023068 |
| Classification: |
C2-set domain containing I-set domain containing CD molecules Sialic acid binding Ig like lectins V-set domain containing |
| Havana BLAST/BLAT: |
OTTHUMG00000031757 |