| known also as: |
Anti-RABBIT ANTI HUMAN FTO |
| known also as: |
RABBIT ANTI HUMAN FTO |
| known also as: |
Lapin ANTI Homo sapiens FTO |
| known also as: |
FTO |
| Other names: |
Alpha-ketoglutarate-dependent dioxygenase FTO, Fat mass and obesity-associated protein, alpha-ketoglutarate-dependent dioxygenase FTO, fat mass and obesity associated, fat mass and obesity-associated protein, protein fto, alpha-ketoglutarate-dependent dioxygenase FTO |
| Gene name: |
FTO |
| Other gene names: |
FTO, KIAA1752, N/A, FTO |
| Category: |
Antibodies |
| Clonality: |
Polyclonal |
| Immunoglobulin isotype: |
Polyclonal IgG |
| Clone: |
Polyclonal antibody |
| Host organism: |
Rabbit |
| Species reactivity: |
Human |
| Specificity and cross-reactivity: |
A negative correlation with the expression of orexin peptide, FTO gene expression has been shown to be highly upregulated in rats after food deprivation, Since then, The gene was named FTO because a deletion in it resulted in fused toes and other abnormalities in mice, _x000D__x000D_The precise function of the gene is unknown but it shows homology with the enzyme AlkB, a 60kDa protein expressed ubiquitously with particularly high levels in the adrenal glands and brain, has also been found, otherwise known as fat mass and obesity-associated protein, some correlation has been shown between carriers of the gene and obesity as well as an increased risk of Type 2 diabetes, which is involved in the stimulation of food intake, which oxidatively demethylates DNA, FTO This item recognises human FTO |
| Form/Appearance: |
Serum (Serum - liquid) |
| Storage and shipping: |
Avoid repeated freezing and thawing as this may denature the antibody, Shelf Life: 18 months from date of dispatch, Should productone contain a precipitate we recommend microcentrifugation before use, Storage in frost-free freezers is not recommended, if preferred, or productone should be stored at -20 degrees Celsius, productone should be stored undiluted, Store at +Store productone at +4 degrees Celsius |
| Tested for:: |
Western Blot (WB), ELISA (EIA) |
| Description: |
Polyclonal antibodies generally are more stable and retain their reactivity under unfavorable conditions, Polyclonal antibodies have series of advantages - larger batches can be supplied at a time, Properly used, To obtain more detailed information on productone, please, refer to the full product datasheet, the time needed for production is considerably shorter, they are inexpensive to manufacture and respectively to buy, this antibody will ensure excellent and reproducible results with guaranteed success for the applications that it is tested in, productone is a polyclonal antibody of high purity and binding affinity for the antigen that it is risen against |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, avoid cycles of freezing and thawing, please, In order to retain the quality and the affinity of productone unchanged |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by MBS Polyclonals_1 they should be stored frozen at - 24° |
| Gene target: |
FTO |
| Short name: |
Anti-HUMAN FTO Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
sapiens fat mass and obesity associated (Antibody to), antibody to-H |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
DNA-N1-methyladenine dioxygenase activity, FTO and IDBG-31147 and ENSG00000140718 and 79068, FTO and IDBG-631892 and ENSBTAG00000012501 and 618622, Fto and IDBG-179938 and ENSMUSG00000055932 and 26383, nuclei, this GO :0001659 and temperature homeostasis and biological process this GO :0005634 and nucleus and cellular component this GO :0006307 and DNA dealkylation involved in DNA repair and biological process this GO :0008198 and ferrous iron binding and molecular function this GO :0010883 and regulation of lipid storage and biological process this GO :0016607 and nuclear speck and cellular component this GO :0035515 and oxidative RNA demethylase activity and molecular function this GO :0035516 and oxidative DNA demethylase activity and molecular function this GO :0035552 and oxidative single-stranded DNA demethylation and biological process this GO :0035553 and oxidative single-stranded RNA demethylation and biological process this GO :0040014 and regulation of multicellular organism growth and biological process this GO :0042245 and RNA repair and biological process this GO :0043734 and DNA-N1-methyladenine dioxygenase activity and molecular function this GO :0044065 and regulation of respiratory system process and biological process this GO :0060612 and adipose tissue development and biological process this GO :0070350 and regulation of white fat cell proliferation and biological process this GO :0070989 and oxidative demethylation and biological process this GO :0080111 and DNA demethylation and biological process, this GO :0008198 : ferrous iron binding, this GO :0008198 : ferrous iron binding and also this GO :0035515 : oxidative RNA demethylase activity and also this GO :0035516 : oxidative DNA demethylase activity and also this GO :0043734 : DNA-N1-methyladenine dioxygenase activity, this GO :0035515 : oxidative RNA demethylase activity, this GO :0035516 : oxidative DNA demethylase activity, this GO :0043734 : DNA-N1-methyladenine dioxygenase activity, fat mass and obesity associated |
| Identity: |
24678 |
| Gene: |
FTO |
More about : FTO |
| Long gene name: |
FTO, alpha-ketoglutarate dependent dioxygenase |
| Synonyms gene name: |
fat mass and obesity associated |
| Synonyms: |
KIAA1752 MGC5149 ALKBH9 |
| Synonyms name: |
alkB homolog 9 alpha-ketoglutarate-dependent dioxygenase |
| Locus: |
16q12, 2 |
| Discovery year: |
2007-04-12 |
| GenBank acession: |
BC003583 |
| Entrez gene record: |
79068 |
| Pubmed identfication: |
17434869 17991826 22002720 |
| RefSeq identity: |
NM_001080432 |
| Classification: |
Alkylation repair homologs |
| Havana BLAST/BLAT: |
OTTHUMG00000158780 |