| known also as: |
Anti-RABBIT ANTI HUMAN SMC1 (pSer966) |
| known also as: |
RABBIT ANTI HUMAN SMC1 (pSer966) |
| known also as: |
Lapin ANTI Homo sapiens SMC1 (pSer966) |
| known also as: |
SMC1 |
| Other names: |
SMC protein 1A, SMC-1-alpha, SMC-1A, SMC1 (structural maintenance of chromosomes 1, SMC1 structural maintenance of chromosomes 1-like 1, Sb1, Structural maintenance of chromosomes protein 1A, segregation of mitotic chromosomes 1, structural maintenance of chromosomes 1A, structural maintenance of chromosomes protein 1A, yeast)-like 1, 8, structural maintenance of chromosomes protein 1A |
| Gene name: |
SMC1 |
| Other gene names: |
CDLS2, DXS423E, DXS423E, KIAA0178, SB1, SB1, SMC protein 1A, SMC-1-alpha, SMC-1A, SMC1, SMC1, SMC1A, SMC1L1, SMC1L1, SMC1alpha, SMCB, 8, 8, SMC1A |
| Category: |
Antibodies |
| Clonality: |
Polyclonal |
| Immunoglobulin isotype: |
Polyclonal IgG |
| Clone: |
Polyclonal antibody |
| Host organism: |
Rabbit |
| Species reactivity: |
Human |
| Specificity and cross-reactivity: |
Eukaryotic SMC1 combines with SMC3, The SMC1-SMC3 heterodimer also combines with DNA polymerase E and ligase III to form the DNA recombination complex RC-1, _x000D_Studies have shown that the phosphorylation of SMC1 on residues Ser966 and Ser957 by the protein kinase ATM, _x000D__x000D_SMC1 is a member of the evolutionary highly conserved SMC family of ATPases which play a vital role in the organization of chromosomes during mitosis, and is required for the activation of the ATM/NBS1-dependent S-phase checkpoint response, and with the two sister-chromatid cohesion proteins Scc1 and Scc3, occurs following irradiation damage of DNA, responsible for the linking of sister chromatids during metaphase, to form the macromolecular cohesion complex, when phosphorylated at Ser966, with the presence of BRCA1 resulting in optimal phosphorylation, SMC1 This item specifically recognises the human nuclear protein SMC1 (structural maintenance of chromosomes 1) |
| Form/Appearance: |
Purified (Purified IgG - liquid) |
| Concentration: |
0mg/ml, IgG concentration 1 |
| Storage and shipping: |
Avoid repeated freezing and thawing as this may denature the antibody, Shelf Life: 18 months from date of dispatch, Should productone contain a precipitate we recommend microcentrifugation before use, Storage in frost-free freezers is not recommended, if preferred, or productone should be stored at -20 degrees Celsius, productone should be stored undiluted, Store at +Store productone at +4 degrees Celsius |
| Tested for:: |
Immunoprecipitation (IP), Western Blot (WB) |
| Description: |
Polyclonal antibodies generally are more stable and retain their reactivity under unfavorable conditions, Polyclonal antibodies have series of advantages - larger batches can be supplied at a time, Properly used, To obtain more detailed information on productone, please, refer to the full product datasheet, the time needed for production is considerably shorter, they are inexpensive to manufacture and respectively to buy, this antibody will ensure excellent and reproducible results with guaranteed success for the applications that it is tested in, productone is a polyclonal antibody of high purity and binding affinity for the antigen that it is risen against |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, avoid cycles of freezing and thawing, please, In order to retain the quality and the affinity of productone unchanged |
| Gene target: |
SMC1 (pSer966) |
| Short name: |
Anti-HUMAN SMC1 (pSer966) |
| Alternative name: |
sapiens SMC1 (pSer966), antibody to-H |