| known also as: |
Anti-RABBIT ANTI HUMAN NBS1 |
| known also as: |
RABBIT ANTI HUMAN NBS1 |
| known also as: |
Lapin ANTI Homo sapiens NBS1 |
| known also as: |
NBS1 |
| Other names: |
Cell cycle regulatory protein p95, Nibrin, Nijmegen breakage syndrome 1 (nibrin), Nijmegen breakage syndrome protein 1, cell cycle regulatory protein p95, nibrin, nibrin, p95 protein of the MRE11/RAD50 complex, nibrin |
| Gene name: |
NBS1 |
| Other gene names: |
AT-V1, AT-V2, ATV, NBN, NBS, NBS, NBS1, NBS1, P95, P95, NBN |
| Category: |
Antibodies |
| Clonality: |
Polyclonal |
| Immunoglobulin isotype: |
Polyclonal IgG |
| Clone: |
Polyclonal antibody |
| Host organism: |
Rabbit |
| Species reactivity: |
Human |
| Specificity and cross-reactivity: |
It is thought that NBS1 is involved in both DNA double-strand break repair and DNA damage-induced checkpoint activation, _x000D__x000D_Mutations in this gene are associated with Nijmegen breakage syndrome, _x000D__x000D_NBS1 interacts with MRE11 and RAD50 to form a complex with nuclease activity which is involved in the initiation of nonhomologous end joining and homologous recombination, also known as nibrin, an autosomal recessive chromosomal instability syndrome characterized by hypersensitivity to ionizing radiation and cancer predisposition, NBS1 This item is specific for human Nijmegen breakage syndrome 1 (NBS1) |
| Form/Appearance: |
Purified (Purified IgG - liquid) |
| Concentration: |
0 mg/ml, IgG concentration 1 |
| Storage and shipping: |
Avoid repeated freezing and thawing as this may denature the antibody, Shelf Life: 18 months from date of dispatch, Should productone contain a precipitate we recommend microcentrifugation before use, Storage in frost free freezers is not recommended, if preferred, or productone should be stored at -20 degrees Celsius, productone should be stored undiluted, Store at +Store productone at +4 degrees Celsius |
| Tested for:: |
Immunoprecipitation (IP), Western Blot (WB) |
| Description: |
Polyclonal antibodies generally are more stable and retain their reactivity under unfavorable conditions, Polyclonal antibodies have series of advantages - larger batches can be supplied at a time, Properly used, To obtain more detailed information on productone, please, refer to the full product datasheet, the time needed for production is considerably shorter, they are inexpensive to manufacture and respectively to buy, this antibody will ensure excellent and reproducible results with guaranteed success for the applications that it is tested in, productone is a polyclonal antibody of high purity and binding affinity for the antigen that it is risen against |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, avoid cycles of freezing and thawing, please, In order to retain the quality and the affinity of productone unchanged |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by MBS Polyclonals_1 they should be stored frozen at - 24° |
| Gene target: |
NBS1 |
| Short name: |
Anti-HUMAN NBS1 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
sapiens NBS1 (Antibody to), antibody to-H |
| Alternative technique: |
antibodies |
| Identity: |
7652 |
| Gene: |
NBN |
More about : NBN |
| Long gene name: |
nibrin |
| Synonyms gene: |
NBS NBS1 |
| Synonyms gene name: |
Nijmegen breakage syndrome 1 (nibrin) |
| Synonyms: |
ATV AT-V2 AT-V1 |
| Locus: |
8q21, 3 |
| Discovery year: |
1997-11-28 |
| GenBank acession: |
AF058696 |
| Entrez gene record: |
4683 |
| Pubmed identfication: |
9590181 9590180 |
| RefSeq identity: |
NM_001024688 |
| Classification: |
BRCA1 C complex MRN complex |
| Havana BLAST/BLAT: |
OTTHUMG00000153546 |
| Locus Specific Databases: |
LOVD - Leiden Open Variation Database LRG_158 |