| Long name: |
AE2 Primary Polyclonal Antibody |
| Also known as: |
AE2 PAb |
| Category: |
Primary Antibodies |
| Conjugation: |
Unconjugated |
| Target Antigen: |
AE2 |
| Specificity: |
This is a highly specific antibody against AE2 |
| Modification(s): |
None |
| Modification site(s): |
Unmodified antibody |
| Clonality: |
Polyclonal antibody |
| Clone number: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Subcellular location: |
Extracellular |
| Source: |
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human AE2/SLC4A2 |
| Gene ID number: |
6522 |
| Tested Applications: |
IF(IHC-P), IHC-P |
| Recommended dilutions: |
IF(IHC-P)(1:50-200), IHC-P(1:100-500) |
| Cross reactivity: |
Human |
| Cross reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen: |
Bicarbonate is secreted from hepatocytes and cholangiocytes through parallel mechanisms, Gene silencing of AE2 causes a marked inhibition of unstimulated and secretin-stimulated chloride/bicarbonate exchange, The AE2 protein regulates pH, The excretion of bicarbonate at both the canaliculi and the bile ducts is an important contributor to the generation of bile-salt independent flow, cell volume and transepithelial ion transport in many tissues, chloride concentration, including hormones, innervation/neuropeptides and biliary constituents, which involve chloride efflux through activation of chloride channels and further bicarbonate secretion via AE2 (also designated SLC4A2)-mediated chloride/bicarbonate exchange, which maintains the bile acid pool that is crucial for secretin to induce bicarbonate-rich choleresis, Primary canalicular bile undergoes a process of fluidization and alkalinization along the biliary tract that is influenced by several factors |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names: |
AE-2, AE2 anion exchanger, Anion exchange protein 2, Anion exchanger 2, B3A2_HUMAN, BND3L, EPB3L1, HKB3, MPB3L, Non-erythroid band 3-like protein, SLC4A2, Solute carrier family 4 member 2, AE 2 |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
AE2 |
| Short name: |
AE2 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
AE2 (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
25076 |
| Gene: |
NBPF3 |
More about : NBPF3 |
| Long gene name: |
neuroblastoma breakpoint family member 3 |
| Synonyms gene name: |
member 3 , neuroblastoma breakpoint family |
| Synonyms: |
AE2 |
| Locus: |
1p36, 12 |
| Discovery year: |
2005-11-23 |
| GenBank acession: |
BC024011 |
| Entrez gene record: |
84224 |
| Pubmed identfication: |
11230166 16079250 |
| RefSeq identity: |
NM_032264 |
| Classification: |
Neuroblastoma breakpoint family |
| Havana BLAST/BLAT: |
OTTHUMG00000002944 |