| Long name: |
MEL18 Primary Polyclonal Antibody |
| Also known as: |
MEL18 PAb |
| Category: |
Primary Antibodies |
| Conjugation: |
Unconjugated |
| Target Antigen: |
MEL18 |
| Specificity: |
This is a highly specific antibody against MEL18 |
| Modification(s): |
None |
| Modification site(s): |
Unmodified antibody |
| Clonality: |
Polyclonal antibody |
| Clone number: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Immunogen range: |
170-210/344 |
| Subcellular location: |
Nucleus |
| Source: |
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human MEL18 |
| Gene ID number: |
7703 |
| Swiss Prot: |
P35227 |
| Tested Applications: |
IF(IHC-P), IHC-P, WB |
| Recommended dilutions: |
IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000) |
| Cross reactivity: |
Mouse, Rat, Human |
| Cross reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen: |
Also plays a role in antero-posterior specification of the axial skeleton and negative regulation of the self-renewal activity of hematopoietic stem cells, Binds specifically to the DNA sequence 5'-GACTNGACT-3', Component of a Polycomb group (PcG) multiprotein PRC1-like complex, Has tumor suppressor activity, Is not functionally redundant with BMI1, May play a role in control of cell proliferation and/or neural cell development, PcG PRC1 complex acts via chromatin remodeling and modification of histones, Regulates proliferation of early T progenitor cells by maintaining expression of HES1, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility, throughout development, unlike BMI1 does not stimulate the E3 ubiquitin-protein ligase activity in a reconstituted PRC1-like complex (By similarity), Transcriptional repressor |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names: |
DNA-binding protein Mel-18, MEL18, PCGF2, Polycomb group RING finger protein 2, RING finger protein 110, RNF110, ZNF144, Zinc finger protein 144, MEL-18 |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
MEL18 |
| Short name: |
MEL18 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
MEL18 (Antibody to) |
| Alternative technique: |
antibodies |