| Long name: |
Midline 1 Primary Polyclonal Antibody |
| Also known as: |
Midline 1 PAb |
| Category: |
Primary Antibodies |
| Conjugation: |
Unconjugated |
| Target Antigen: |
Midline-1 |
| Specificity: |
This is a highly specific antibody against Midline-1 |
| Modification(s): |
None |
| Modification site(s): |
Unmodified antibody |
| Clonality: |
Polyclonal antibody |
| Clone number: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Source: |
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human Midline-1/RNF59 |
| Gene ID number: |
4281 |
| Tested Applications: |
IF(IHC-P), IHC-P, WB |
| Recommended dilutions: |
IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000) |
| Cross reactivity: |
Mouse, Rat, Human |
| Cross reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen: |
Defects in MID1 are the cause of Opitz syndrome type I (OS-I), It also interacts with IGBP1 (Lymphocyte signaling protein A4), It is a cytoplasmic protein found as a homodimer or heterodimer with Midline-2, Midline-1 belongs to the TRIM/RBCC family and contains two B box-type zinc fingers, Midline-1 is believed to have E3 ubiquitin ligase activity which targets the catalytic subunit of protein phosphatase 2 for degradation, OS-I is an X-linked recessive disorder characterized by hypertelorism, OS-I mutations produce proteins with a decreased affinity for microtubules, Putative transcription factor XPRF, RING finger protein 59) is a 667 amino acid protein encoded by the human gene MID1, developmental delay and congenital heart defects, genital-urinary defects such as hypospadias in males and splayed labia in females, imperforate anus, lip-palate-laryngotracheal clefts, one B30, one COS domain, one fibronectin type-III domain and one RING-type zinc finger, 2/SPRY domain, Midline-1 (Tripartite motif-containing protein 18 |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names: |
BBBG1, FXY, Finger on X and Y mouse homolog of antibody, GBBB 1, GBBB1, MID 1, MID-1, Mid1, Midin, Midline 1, Midline 1 Opitz/BBB syndrome, Midline 1 RING finger protein, Midline 1 ring finger, Midline-1, Midline1, OGS 1, OGS1, OS antibody, OSX, Putative transcription factor XPRF, RING finger protein 59, RNF 59, RNF59, TRI18, TRI18_HUMAN, TRIM 18, TRIM18, Tripartite mot containing protein 18, Tripartite mot protein TRIM18, Tripartite mot-containing protein 18, XPRF, ZNFXY, Zinc finger X and Y antibody, BBBG 1 |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
Midline 1 |
| Short name: |
Midline 1 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
Midline 1 (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
7095 |
| Gene: |
MID1 |
More about : MID1 |
| Long gene name: |
midline 1 |
| Synonyms: |
OS FXY TRIM18 RNF59 |
| Synonyms name: |
Opitz/BBB syndrome |
| Locus: |
Xp22 |
| Discovery year: |
1997-12-12 |
| GenBank acession: |
Y13667 |
| Pubmed identfication: |
9354791 9425238 |
| Classification: |
Tripartite motif containing Ring finger proteins Fibronectin type III domain containing |
| Havana BLAST/BLAT: |
OTTHUMG00000021127 |
| Locus Specific Databases: |
Mental Retardation database |