| Long name: |
ALEXA FLUOR 350 Conjugated, GPBAR1 Polyclonal Antibody |
| Also known as: |
Anti-GPCR TGR5/GPBAR1 PAb ALEXA FLUOR 350 |
| Category: |
Conjugated Primary Antibodies |
| Conjugated with: |
350, ALEXA FLUOR® |
| Host Organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Antigen: |
GPCR TGR5/GPBAR1 |
| Specificity: |
This is a highly specific antibody against GPCR TGR5/GPBAR1 |
| Modification: |
Unmodified |
| Modification Site: |
None |
| Clonality: |
Polyclonal |
| Clone: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Subcellular location: |
Extracellular |
| Source: |
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human GPBAR1 |
| Gene ID Number: |
151306 |
| Tested applications: |
IF(IHC-P), FCM |
| Recommended dilutions: |
IF(IHC-P)(1:50-200), FCM(1:20-100) |
| Crossreactivity: |
Human |
| Cross-reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the antigen: |
Bile acids activate mitogen-activated protein (MAP) kinase pathways, Bile acids also provoke TGR5 to suppress macrophage functions, TGR5 is sensitive to bile acids and responds through a significant mechanism that coordinates energy homeostasis, TGR5-controlled signaling pathways may be good candidates for drug targets to treat common metabolic diseases, and atherosclerosis, and cause rapid intracellular cAMP production, and leukocytes, but not in brain, colon (without mucosa), hyperlipidemia, kidney, liver, or lung, placenta, promote an increase of guanosine 5'-O-3-thio-triphosphate binding in membrane fractions, skeletal muscle, small intestine, specifically induce TGR5 internalization, spleen, such as obesity, thymus, type II diabetes, The G protein-coupled receptor TGR5 is a 330-amino acid protein that is almost universally expressed in human tissues including heart |
| Purification: |
Purified by Protein A |
| Storage conditions: |
50% glycerol and 0, Keep refrigerated at 2 to 8 degrees Celcius for up to one year, 09% sodium azide, Store this antibody in aqueous buffered solution containing 1% BSA |
| Excitation emission: |
343nm/442nm |
| Synonyms: |
BG37 GPCR TGR5 M-BAR GPCR19 GPR131 MGC40597 |
| Properties: |
ALEXA FLUOR they should be stored frozen at - 24°, Alexa Fluor 350 conjugates can be used in multi-color flow cytometry with FACS's equipped with a second red laser or red diode, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies, C, C for long term storage and for short term at + 5°, For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
ALEXA FLUOR 350, Alexa Fluor |
| Gene target: |
GPBAR1 |
| Short name: |
GPBAR1 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Label: |
ALEXA FLUOR 350 |
| Alternative name: |
ALEXA FLUOR 350, GPBAR1 (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
19680 |
| Gene: |
GPBAR1 |
More about : GPBAR1 |
| Long gene name: |
G protein-coupled bile acid receptor 1 |
| Locus: |
2q35 |
| Discovery year: |
2003-01-24 |
| GenBank acession: |
AB086170 |
| Entrez gene record: |
151306 |
| Pubmed identfication: |
12419312 |
| RefSeq identity: |
NM_001077191 |
| Classification: |
G protein-coupled bile acid receptor |
| Havana BLAST/BLAT: |
OTTHUMG00000155203 |