| Long name: |
GPBAR1 Primary Polyclonal Antibody |
| Also known as: |
GPBAR1 PAb |
| Category: |
Primary Antibodies |
| Conjugation: |
Unconjugated |
| Target Antigen: |
GPCR TGR5/GPBAR1 |
| Specificity: |
This is a highly specific antibody against GPCR TGR5/GPBAR1 |
| Modification(s): |
None |
| Modification site(s): |
Unmodified antibody |
| Clonality: |
Polyclonal antibody |
| Clone number: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Subcellular location: |
Extracellular |
| Source: |
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human GPBAR1 |
| Gene ID number: |
151306 |
| Tested Applications: |
FCM, IF(IHC-P), IHC-P, WB |
| Recommended dilutions: |
FCM(1:20-100), IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000) |
| Cross reactivity: |
Human |
| Cross reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen: |
Bile acids activate mitogen-activated protein (MAP) kinase pathways, Bile acids also provoke TGR5 to suppress macrophage functions, TGR5 is sensitive to bile acids and responds through a significant mechanism that coordinates energy homeostasis, TGR5-controlled signaling pathways may be good candidates for drug targets to treat common metabolic diseases, and atherosclerosis, and cause rapid intracellular cAMP production, and leukocytes, but not in brain, colon (without mucosa), hyperlipidemia, kidney, liver, or lung, placenta, promote an increase of guanosine 5'-O-3-thio-triphosphate binding in membrane fractions, skeletal muscle, small intestine, specifically induce TGR5 internalization, spleen, such as obesity, thymus, type II diabetes, The G protein-coupled receptor TGR5 is a 330-amino acid protein that is almost universally expressed in human tissues including heart |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names: |
BG37, G protein coupled bile acid receptor 1, G protein coupled bile acid receptor BG 37, G protein coupled bile acid receptor BG37, G-protein coupled bile acid receptor 1, G-protein coupled receptor GPCR19, GPBAR 1, GPBAR1, GPBAR_HUMAN, GPCR, GPCR 19, GPCR19, GPR 131, GPR131, M BAR, M-BAR, MGC40597, Membrane bile acid receptor, Membrane type receptor for bile acids, Membrane-type receptor for bile acids, TGR 5, TGR5, hBG 37, hBG37, hGPCR 19, hGPCR19, BG 37 |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
GPBAR1 |
| Short name: |
GPBAR1 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
GPBAR1 (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
19680 |
| Gene: |
GPBAR1 |
More about : GPBAR1 |
| Long gene name: |
G protein-coupled bile acid receptor 1 |
| Synonyms: |
BG37 GPCR TGR5 M-BAR GPCR19 GPR131 MGC40597 |
| Locus: |
2q35 |
| Discovery year: |
2003-01-24 |
| GenBank acession: |
AB086170 |
| Entrez gene record: |
151306 |
| Pubmed identfication: |
12419312 |
| RefSeq identity: |
NM_001077191 |
| Classification: |
G protein-coupled bile acid receptor |
| Havana BLAST/BLAT: |
OTTHUMG00000155203 |